Covance understands that preformulation or formulation failure may lead to delays or holds of preclinical or clinical development programs. That is why the Covance team provides you with the same full preformulation and formulation development services afforded to top-five pharma companies with full support from our sites in Porcheville, France and Alnwick, UK. Our CMC facilities are fully GMP compliant.

Center of Excellence. Our site at Alnwick, UK is a Formulation Center of Excellence with our purpose-built 13,000 sq ft (1,200m2) facility and world-renowned scientists. Our senior scientists have an average of 27 years of pharmaceutical experience, including over 15 years of experience working closely under one roof to ensure smooth progress of your drug product development.

Capabilities designed for your success include:

  • Preformulation
    • Salt screening
    • Polymorph screening
    • Solubility
    • API – excipient interaction
    • Novel technologies for highly insoluble APIs (nano technology)
  • Formulation development
    • IV and oral preclinical formulations
    • Clinical formulations
      • Solid
      • Semi-solid
      • Oral Liquids
      • Sterile (aseptically prepared) liquids
    • Process development studies
    • 14C labeled and cytotoxic formulations
    • Process scale-up studies
  • Analytical support for preformulation and formulation development, including method development and validation
  • Microbiological testing

Highlights of key facilities and instrumentation:

  • Separate laboratories for non-radiolabelled and radiolabeled materials
  • X-Ray powder diffraction system
  • Thermo-gravimetric analysis, differential scanning calorimetry
  • 400 MHz and 500 MHz NMR spectrometers
  • Solid state NMR
  • ICP-MS / LC-ICP-MS
  • Variety of spectrometers and mass spectrometers
  • Variety of chromatography systems with variety of detection systems
  • Hot stage microscope
  • Dynamic vapor absorption/desorption system
  • ICH compliant stability suite

Service Profile

Covance has a dedicated team of scientists for API preformulation and drug product formulation development. Download a service profile to learn more.

Biomolecules

Develop, characterize, test and validate with Covance, no matter what technique or molecule you're pursuing. Our experience covers a wide range of biomolecules, including: