Analyte Species Matrix LLOQ-
ULOQ		 Validated Sample Vol. (mL) Method Anti-
coagulant
V 1'-Hydroxymidazolam Human P 0.100-
100 ng/mL		 0.200 LC-
MS/MS		 2, 5, 6
V 1'-Hydroxymidazolam Human P 0.100-
100 ng/mL		 0.400 LC-
MS/MS		 2, 6
V 2'difluoro-2', 2'-deoxyuridine (dFdU) Human P 50.0-
50,000 ng/mL		 0.050 LC-
MS/MS		 2, 6
V 2-Hydroxydesipramine Human P 0.250-
100 ng/mL		 0.100 LC-
MS/MS		 2
V 4-Hydroxydiclofenac Human P 5.00-
2,500 ng/mL		 0.050 LC-
MS/MS		 2
V 4-Hydroxymidazolam Human P 0.100-
100 ng/mL		 0.400 LC-
MS/MS		 2, 6
V 5-Aminosalicylic Acid Human P 0.0250-
2.50 µg/mL		 0.025 LC-
MS/MS		 6
V 5-Hydroxyindole-3-acetic acid (5-HIAA) Human P 1.00-
200 ng/mL		 0.100 LC-
MS/MS		 2
V 5-Hydroxyomeprazole Human P 2.50-
2,500 ng/mL		 0.050 LC-
MS/MS		 6
V 5-Hydroxyomeprazole Human P 0.500-
1,000 ng/mL		 0.050 LC-
MS/MS		 2
V 6-beta-hydroxycortisol Human U 50.0-
10,000 ng/mL		 0.025 LC-
MS/MS		 N
V 6-beta-hydroxycortisol Human U 5.00-
1,000 ng/mL		 0.050 LC-
MS/MS		 N
V 7-Hydroxymethotrexate Human P 1.00-
250 ng/mL		 0.050 LC-
MS/MS		 5
V Abacavir P 2.50-
5,000 ng/mL		 0.050 LC-
MS/MS		 2
V Acetaminophen Dog DBS 0.100-
50.0 µg/mL		 0.030 LC-
MS/MS		 2
R Acetaminophen Dog P 0.100-
50.0 µg/mL		 0.025 LC-
MS/MS		 2
R Acetaminophen Rat P 0.100-
50.0 µg/mL		 0.025 LC-
MS/MS		 2
V Acetaminophen Rat DBS 0.100-
50.0 µg/mL		 0.030 LC-
MS/MS		 2
V Acetaminophen Rat WB 0.100-
50.0 µg/mL		 0.025 LC-
MS/MS		 2
V Acetaminophen Rat WB 0.100-
50.0 µg/mL		 0.020 LC-
MS/MS		 2
V Acetaminophen Human P 50.0-
50,000 ng/mL		 0.050 LC-
MS/MS		 2
V Adefovir Human S 1.00-
200 ng/mL		 0.100 LC-
MS/MS		 N
V Adefovir Human P 0.250-
50.0 ng/mL		 0.150 LC-
MS/MS		 2
V Albuterol Human S 50.0-
10,000 pg/mL		 0.400 LC-
MS/MS		 N
V Aldosterone Human P 10.0-
5,000 pg/mL		 0.200 LC-
MS/MS		 2
V Alprazolam Human P 0.100-
50.0 ng/mL		 0.100 LC-
MS/MS		 2
V Alprazolam Human P 0.100-
100 ng/mL		 0.050 LC-
MS/MS		 2
V Amlodipine Human P 0.0500-
25.0 ng/mL		 0.200 LC-
MS/MS		 2
V Amphetamine Human P 0.100-
50.0 ng/mL		 0.250 LC-
MS/MS		 5
V Amprenavir Human P 10.0-
10,000 ng/mL		 0.100 LC-
MS/MS		 6
V Amprenavir Human P 10.0-
10,000 ng/mL		 0.100 LC-
MS/MS		 6
V Amrubicin Human P 2.00-
2,000 ng/mL		 0.200 LC-
MS/MS		 2
V Amrubicinol Human P 2.00-
400 ng/mL		 0.200 LC-
MS/MS		 2
V Anastrozole Human P 1.00-
100 ng/mL		 0.100 LC-
MS/MS		 6
V Aripiprazole Human P 1.00-
1,000 ng/mL		 0.100 LC-
MS/MS		 2
V Atazanavir Human P 1.00-
1,000 ng/mL		 0.100 LC-
MS/MS		 2
V Atorvastatin Human P 0.250-
100 ng/mL		 0.100 LC-
MS/MS		 5
V Atorvastatin, ortho-
hydroxy 		Human P 0.250-
100 ng/mL		 0.100 LC-
MS/MS		 5
V Atorvastatin, para-
hydroxy		 Human P 0.250-
100 ng/mL		 0.100 LC-
MS/MS		 5
V Azithromycin Human P 0.500-
500 ng/mL		 0.100 LC-
MS/MS		 2
R Bufuralol Human (inhibition) HM 0.0250-
1.00 µM		 0.010 LC-
MS/MS		 N
V Caffeine Human P 25.0-
20,000 ng/mL		 0.100 LC-
MS/MS		 2, 5
V Carboplatin Human P 2.00-
2,000 ng/mL		 0.050 LC-
MS/MS		 6
Cassette Dosing
3 Compounds
R Midazolam Human (inhibition) HM 0.0500-
5.00 µM		 0.010 LC-
MS/MS		 N
R Dextromethorphan Human (inhibition) HM 0.0500-
5.00 µM		 0.010 LC-
MS/MS		 N
R Chlorzoxazone Human (inhibition) HM 0.100-
10.0 µM		 0.010 LC-
MS/MS		 N
5 Compounds
R Midazolam Human (inhibition) HM 0.0500-
5.00 µM		 0.010 LC-
MS/MS		 N
R Dextromethorphan Human (inhibition) HM 0.0500-
5.00 µM		 0.010 LC-
MS/MS		 N
R Chlorzoxazone Human (inhibition) HM 0.100-
10.0 µM		 0.010 LC-
MS/MS		 N
R Coumarin Human (inhibition) HM 0.100-
10.0 µM		 0.010 LC-
MS/MS		 N
R Tolbutamide Human (inhibition) HM 0.0500-
5.00 µM		 0.010 LC-
MS/MS		 N
V Celecoxib Human P 5.00-
2,000 ng/mL		 0.200 LC-
MS/MS		 2
V Cetirizine Human P 1.00-
1,000 ng/mL		 0.100 LC-
MS/MS		 6
V Citalopram Human P 0.500-
200 ng/mL		 0.100 LC-
MS/MS		 2
V Cortisol Human U 1.00-
200 ng/mL		 0.050 LC-
MS/MS		 N
V Cortisol Human U 1.00-
100 ng/mL		 0.200 LC-
MS/MS		 N
V Cortisol Human U 3.00-
200 ng/mL		 0.025 LC-
MS/MS		 N
V Cotinine Human P 10.0-
2,000 ng/mL		 0.250 LC-
MS/MS		 2
V Cyclosporin A Human WB 5.00-
2,000 ng/mL		 0.100 LC-
MS/MS		 2
V Dapsone Human P 5.00-
2,000 ng/mL		 0.100 LC-
MS/MS		 2
V Debrisoquine Human P 5.00-
2,000 ng/mL		 0.100 LC-
MS/MS		 2
V Descarboethoxy Loratadine Human P 25.0-
25,000 pg/mL		 0.200 LC-
MS/MS		 6
V Desipramine Human P 0.250-
100 ng/mL		 0.100 LC-
MS/MS		 2
V Desmethyl Diazepam Human P 1.00-
500 ng/mL		 0.100 LC-
MS/MS		 2
V Desmethyl Sertraline Human P 0.500-
100 ng/mL		 0.250 LC-
MS/MS		 6
V Desmethyl Sildenafil Human P 1.00-
500 ng/mL		 0.100 LC-
MS/MS		 5, 6
V Desmethyl Sildenafil Human UF 0.200-
100 ng/mL		 0.100 LC-
MS/MS		 5
V Desmethyl Venlafaxine Human P 1.00-
500 ng/mL		 0.050 LC-
MS/MS		 6
V Dexamethasone Human P 0.250-
250 ng/mL		 0.100 LC-
MS/MS		 2, 6
R Dextromethorphan Human (inhibition) HM 0.0500-
5.00 µM		 0.005 LC-
MS/MS		 N
V Dextromethorphan Human P 0.100-
25.0 ng/mL		 0.200 LC-
MS/MS		 2
V Dextromethorphan Human P 0.0100-
10.0 ng/mL		 0.100 LC-
MS/MS		 6
V   Dextrorphan Human P 5.00-
2,500 ng/mL		 0.050 LC-
MS/MS		 2
V   Dextrorphan Human P 0.300-
300 ng/mL		 0.100 LC-
MS/MS		 6
V Diazepam Human P 1.00-
500 ng/mL		 0.100 LC-
MS/MS		 2
V Diclofenac Human P 5.00-
2,500 ng/mL		 0.050 LC-
MS/MS		 2
R Diclofenac Human (inhibition) HM 0.0500-
5.00 µM		 0.010 LC-
MS/MS		 N
V Didanosine Human P 5.00-
2,000 ng/mL		 0.100 LC-
MS/MS		 6, 2
V Digoxin Human P 0.100-
10.0 ng/mL		 0.250 LC-
MS/MS		 2
V Digoxin Human U 0.500-
100 ng/mL		 0.500 LC-
MS/MS		 N
V Diphenhydramine Human P 0.500-
200 ng/mL		 0.100 LC-
MS/MS		 2
V Dipyridamole Human P 5.00-
3,000 ng/mL		 0.050 LC-
MS/MS		 2
V Docetaxel Human P 10.0-
10,000 ng/mL		 0.050 LC-
MS/MS		 2
V Donepezil Human P 0.500-
250 ng/mL		 0.050 LC-
MS/MS		 2
V Duloxetine Human P 0.100-
100 ng/mL		 0.050 LC-
MS/MS		 6
V Efavirenz Human P 1.00-
1,000 ng/mL		 0.100 LC-
MS/MS		 2
V Emtricitabine Human P 10.0-
5,000 ng/mL		 0.100 LC-
MS/MS		 2
V Ethambutol Human P 10.0-
5,000 ng/mL		 0.050 LC-
MS/MS		 2
V Erlotinib Human P 2.00-
2,000 ng/mL		 0.100 LC-
MS/MS		 2, 6
V Ethinyl Estradiol Human P 7.50-
500 pg/mL		 0.500 LC-
MS/MS		 2
V Ethinyl Estradiol Human P 2.50-
500 pg/mL		 0.500 LC-
MS/MS		 2
V Fluoxetine Human P 0.500-
250 ng/mL		 0.100 LC-
MS/MS		 2, 6
V/C Follicle Stimulating Hormone (FSH), TOSOH Human S 1.00-
200 miu/mL		 0.400 IMMU N
V Gefitinib Human P 5.00-
1,000 ng/mL		 0.100 LC-
MS/MS		 5
V Gefitinib Human P 5.00-
1,000 ng/mL		 0.100 LC-
MS/MS		 6
V Gemcitabine Human P 50.0-
50,000 ng/mL		 0.050 LC-
MS/MS		 2, 6
V Hydrochlorothiazide Human P 1.00-
1,000 ng/mL		 0.100 LC-
MS/MS		 5
V Hydrocodone Human P 0.100-
100 ng/mL		 0.100 LC-
MS/MS		 2
V Hydromorphone Human P 0.100-
100 ng/mL		 0.100 LC-
MS/MS		 2
V Hydroxyacid Simvastatin Human P 0.100-
25.0 ng/mL		 0.250 LC-
MS/MS		 2
V IL-1β Human S 15.0-
5,000 pg/mL		 0.200 ECL N
V IL-6 Human S 15.0-
5,000 pg/mL		 0.200 ECL N
V Indinavir Human P 2.00-
400 ng/mL		 0.500 LC-
MS/MS		 6
V Indinavir Human P 10.0-
10,000 ng/mL		 0.100 LC-
MS/MS		 6
V Iohexol Human P 1.00-
500 µg/mL		 0.050 LC-
MS/MS		 2
V Iohexol Human U 2.00-
1,000 µg/mL		 0.050 LC-
MS/MS		 N
V Ketamine Human P 0.500-
500 ng/mL		 0.200 LC-
MS/MS		 2
V Ketoconazole Human P 5.00-
1,000 ng/mL		 0.100 LC-
MS/MS		 2, 6
V Lamivudine Human P 2.50-
5,000 ng/mL		 0.050 LC-
MS/MS		 2
V Lamotrigine Human P 25.0-
12,500 ng/mL		 0.100 LC-
MS/MS		 2
V Levonorgestrel Human P 150-
10,000 pg/mL		 0.500 LC-
MS/MS		 2
V Levonorgestrel Human P 50.0-
10,000 pg/mL		 0.500 LC-
MS/MS		 2
V Lopinavir Human P 20.0-
20,000 ng/mL		 0.050 LC-
MS/MS		 6
V Lopinavir Human P 20.0-
20,000 ng/mL		 0.050 LC-
MS/MS		 2
V Loratadine Dog P 20.0-
20,000 pg/mL		 0.100 LC-
MS/MS		 5
V Loratadine Monkey P 20.0-
20,000 pg/mL		 0.100 LC-
MS/MS		 5
V Loratadine Rat P 20.0-
20,000 pg/mL		 0.100 LC-
MS/MS		 5
V Loratadine Human P 10.0-
1,000 pg/mL		 1.000 LC-
MS/MS		 6
V Loratadine Monkey DBS 0.500-
1,000 ng/mL		 0.030 LC-
MS/MS		 5
V Loratadine Human P 10.0-
10,000 pg/mL		 0.200 LC-
MS/MS		 6
V Losartan Human P 2.00-
1,000 ng/mL		 0.100 LC-
MS/MS		 5
V Losartan Carboxylic Acid Human P 2.00-
1,000 ng/mL		 0.100 LC-
MS/MS		 5
R Mephenytoin Human (inhibition) HM 0.0500-
10.0 µM		 0.010 LC-
MS/MS		 N
V Metformin Human P 2.00-
2,000 ng/mL		 0.025 LC-
MS/MS		 6
V Methamphetamine Human P 0.100-
50.0 ng/mL		 0.250 LC-
MS/MS		 5
V Methotrexate Human P 1.00-
250 ng/mL		 0.050 LC-
MS/MS		 5
V Methylphenidate (d-threo-) Human P 0.250-
50.0 ng/mL		 0.500 LC-
MS/MS		 2
V Methylphenidate (l-threo-) Human P 0.250-
50.0 ng/mL		 0.500 LC-
MS/MS		 2
V Midazolam Human P 0.100-
100 ng/mL		 0.100 LC-
MS/MS		 2
V Midazolam Human P 0.0500-
50.0 ng/mL		 0.200 LC-
MS/MS		 6
R Midazolam Human (inhibition) HM 0.0250-
1.00 µM		 0.015 LC-
MS/MS		 N
V Minoxidil Human S 0.250-
25.0 ng/mL		 0.100 LC-
MS/MS		 N
V Modafinil Human P 0.100-
50.0 ug/mL		 0.025 LC-
MS/MS		 2
V Morphine Human P 0.500-
50.0 ng/mL		 0.250 LC-
MS/MS		 3, 5, 6
V Morphine-6-β-Glucuronide Human P 1.00-
100 ng/mL		 0.250 LC-
MS/MS		 3, 5, 6
V Morphine-3-β-Glucuronide Human P 10.0-
1,000 ng/mL		 0.250 LC-
MS/MS		 3, 5, 6
V Moxifloxacin Human P 25.0-
5,000 ng/mL		 0.050 LC-
MS/MS		 3, 5, 6, 7
V Moxifloxacin Human P 25.0-
5,000 ng/mL		 0.050 LC-
MS/MS		 2
V Nelfinavir Human P 10.0-
10,000 ng/mL		 0.100 LC-
MS/MS		 6
V Nicotine Human P 1.00-
200 ng/mL		 0.250 LC-
MS/MS		 2
V NNAL, total Human U 10.0-
2,500 pg/mL		 2.000 LC-
MS/MS		 N
V Norelgestromin Human P 50.0-
25,000 pg/mL		 0.500 LC-
MS/MS		 7
V Norketamine Human P 0.500-
500 ng/mL		 0.200 LC-
MS/MS		 2
V Noroxycodone Human P 0.100-
50.0 ng/mL		 0.400 LC-
MS/MS		 2
V Olanzapine Human P 0.250-
100 ng/mL		 0.050 LC-
MS/MS		 2
V Omeprazole Human P 0.500-
1,000 ng/mL		 0.050 LC-
MS/MS		 2
V Ondansetron Human P 0.100-
50.0 ng/mL		 0.100 LC-
MS/MS		 2
V Oxycodone Human P 0.100-
50.0 ng/mL		 0.400 LC-
MS/MS		 2
V Oxymorphone Human P 0.100-
50.0 ng/mL		 0.400 LC-
MS/MS		 2
V Paclitaxel Human P 10.0-
2,000 ng/mL		 0.250 LC-
MS/MS		 2, 6
V Paclitaxel Human P 10.0-
10,000 ng/mL		 0.050 LC-
MS/MS		 6
V Paraxanthine Human P 25.0-
20,000 ng/mL		 0.100 LC-
MS/MS		 2, 5
V Paroxetine Human P 0.050.0-
50.0 ng/mL		 0.100 LC-
MS/MS		 6, 2
R Phenacetin Human (inhibition) HM 0.150-
5.00 µM		 0.010 LC-
MS/MS		 N
V Phentermine Human P 0.500-
500 ng/mL		 0.150 LC-
MS/MS		 2
V Pioglitazone Rat DBS 5.00-
2,500 ng/mL		 0.020 LC-
MS/MS		 4
V Pioglitazone Human P 2.50-
2,500 ng/mL		 0.100 LC-
MS/MS		 2
V Platinum Human P 1.00-
1,000 ng/mL		 0.100 ICP-
MS		 5, 6
V Platinum Human PUF 1.00-
1,000 ng/mL		 0.100 ICP-
MS		 5, 6
V Platinum Human CSF 1.00-
1,000 ng/mL		 0.100 ICP-
MS		 5, 6
V Platinum Human U 100-
25,000 ng/mL		 0.050 ICP-
MS		 N
V Pseudoephedrine Human P 5.00-
500 ng/mL		 0.100 LC-
MS/MS		 6
V Pyrazinamide Human P 50.0-
25,000 ng/mL		 0.050 LC-
MS/MS		 2
V Quetiapine Human P 0.500-
1,000 ng/mL		 0.100 LC-
MS/MS		 2, 5, 6
V Raltegravir Human P 1.00-
1,500 ng/mL		 0.100 LC-
MS/MS		 2
V Ribavirin Human P 10.0-
10,000 ng/mL		 0.100 LC-
MS/MS		 2
V Rifampicin Human P 50.0-
35,000 ng/mL		 0.025 LC-
MS/MS		 1
V Ritonavir Human P 10.0-
2,000 ng/mL		 0.050 LC-
MS/MS		 2
V Ritonavir Human P 10.0-
2,000 ng/mL		 0.050 LC-
MS/MS		 6
V Ritonavir Human P 10.0-
10,000 ng/mL		 0.100 LC-
MS/MS		 6
V Ritonavir Human P 10.0-
10,000 ng/mL		 0.100 LC-
MS/MS		 6
V Ropinirole Human P 20.0-
5,000 pg/mL		 0.100 LC-
MS/MS		 2
V Rosiglitazone Human P 1.00-
1,000 ng/mL		 0.050 LC-
MS/MS		 2
V Saquinavir Human P 10.0-
10,000 ng/mL		 0.100 LC-
MS/MS		 6
V Scopolamine Human P 0.050-
10.0 ng/mL		 0.100 LC-
MS/MS		 6
V Sertraline Human P 0.250-
100 ng/mL		 0.250 LC-
MS/MS		 6
V Sildenafil Human P 1.00-
500 ng/mL		 0.100 LC-
MS/MS		 5, 6
V Sildenafil Human UF 0.200-
100 ng/mL		 0.100 LC-
MS/MS		 5
V Simvastatin Human P 0.100-
25.0 ng/mL		 0.250 LC-
MS/MS		 2
V Simvastatin Human P 0.0500-
50.0 ng/mL		 0.250 LC-
MS/MS		 6
V Simvastatin Acid Human P 0.0500-
10.0 ng/mL		 0.250 LC-
MS/MS		 6
V Sitagliptin Human P 0.500-
1,000 ng/mL		 0.100 LC-
MS/MS		 2
V Sorafenib Human S 0.100-
50.0 ng/mL		 0.050 LC-
MS/MS		 N
V Sorafenib Human P 0.100-
50.0 µg/mL		 0.050 LC-
MS/MS		 2, 5, 6
V Sulfapyridine Human P 0.500-
50.0 µg/mL		 0.025 LC-
MS/MS		 6
V Sulfapyridine Human P 0.500-
20.0 µg/mL		 0.100 LC-
MS/MS		 5
V Sulfasalazine Human P 0.500-
50.0 µg/mL		 0.025 LC-
MS/MS		 6
V Sulfasalazine Human P 0.500-
20.0 µg/mL		 0.100 LC-
MS/MS		 5
V Sumatriptan Human P 0.200-
200 ng/mL		 0.100 LC-
MS/MS		 5
V Tadalafil Human P 1.00-
500 ng/mL		 0.100 LC-
MS/MS		 6
V Tenofovir Human P 1.00-
200 ng/mL		 0.100 LC-
MS/MS		 2
V Testosterone Human S 20.0-
5,000 ng/dL		 0.500 LC-
MS/MS		 N
V Theophylline Human P 5.00-
2,000 ng/mL		 0.100 LC-
MS/MS		 2, 6
V TNF-α Human S 5.00-
5,000 pg/mL		 0.050 ECL N
V TNF-α Human S 15.0-
5,000 pg/mL		 0.200 ECL N
V Tolbutamide Human P 5.00-
2,000 ng/mL		 0.100 LC-
MS/MS		 2
V Topiramate Human P 0.0200-
20.0 µg/mL		 0.100 LC-
MS/MS		 2
V Triazolam Human P 0.100-
50.0 ng/mL		 0.200 LC-
MS/MS		 5
V Valproic Acid Human P 0.200-
100 ug/mL		 0.100 LC-
MS/MS		 2
V Vancomycin Human P 10.0-
10,000 ng/mL		 0.050 LC-
MS/MS		 2
V Vardenafil Human P 0.200-
200 ng/mL		 0.100 LC-
MS/MS		 2
V Venlafaxine Human P 1.00-
500 ng/mL		 0.050 LC-
MS/MS		 6
V Vigabatrin Human P 0.200-
200 µg/mL		 0.050 LC-
MS/MS		 2
V Vinorelbine Human P 0.500-
200 ng/mL		 0.200 LC-
MS/MS		 2
V Voriconazole Human P 5.00-
5,000 ng/mL		 0.050 LC-
MS/MS		 6
V Warfarin (R-) Human P 5.00-
1,500 ng/mL		 0.250 LC-
MS/MS		 3
V Warfarin (S-) Human P 5.00-
1,500 ng/mL		 0.250 LC-
MS/MS		 3
V Zaleplon Human P 1.00-
200 ng/mL		 0.050 LC-
MS/MS		 2
V Ziprasidone Human P 0.500-
1,000 ng/mL		 0.100 LC-
MS/MS		 2
V Zolpidem Human P 1.00-
400 ng/mL		 0.500 LC-
MS/MS		 2
V Zolpidem Human P 0.500-
100 ng/mL		 0.150 LC-
MS/MS		 2, 5, 6, 8