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Immune response_IL-4 signaling pathway [score: 1 (0%)]

Interleukin-4 (IL-4) is a T cell derived multifunctional cytokine that plays a critical role in the regulation of immune responses. IL-4 induces Th2 (T helper 2) differentiation, causes macrophage suppression, and stimulates B cell production of Immunoglobulins E, G1 and G4 (IgE, ...

Immune response_MIF-JAB1 signaling [score: 1 (0%)]

Macrophage migration inhibitory factor (MIF) is a pluripotent cytokine involved in inflammation and immune responses as well as in growth factor-dependent cell proliferation, cell cycle, angiogenesis, and tumorigenesis [1], [2], [3], ...

Cytokine production by Th17 cells in CF [score: 1 (0%)]

Cystic Fibrosis (CF) is a potentially lethal genetic disease that typically results in the development of bronchial inflammation, bronchiectasis, the progressive loss of lung function and, ultimately, death [1].

CF is caused by genetic defects in Cystic Fibrosis ...

Bacterial infections in CF airways [score: 1 (0%)]

The upper airways represent a primary site for the introduction of pathogenic microorganisms from inspired air. The ciliated epithelium features several powerful mechanisms for prevention of colonization by inhaled bacteria, thus the lower respiratory tract usually remains sterile [1].

Defective ...

Mucin expression in CF via TLRs, EGFR signaling pathways [score: 1 (0%)]

Cystic Fibrosis (CF) is a potentially lethal genetic disease that typically results in the development of bronchial inflammation, bronchiectasis, the progressive loss of lung function and ultimately death [1].

CF was initially called "mucoviscidosis" because of ...

Immune response_Bacterial infections in normal airways [score: 1 (0%)]

The upper airways represent a primary site for the introduction of pathogenic microorganisms from inspired air. The ciliated epithelium features several powerful mechanisms for prevention of colonization by inhaled bacteria, thus the lower respiratory tract usually remains sterile. Toll-like receptors ...

Cytokine production by Th17 cells in CF (Mouse model) [score: 1 (0%)]

Cystic Fibrosis (CF) is a potentially lethal genetic disease that typically results in the development of bronchial inflammation, bronchiectasis, the progressive loss of lung function and, ultimately, death [1].

CF is caused by genetic defects in Cystic Fibrosis ...

Immune response_IL-12-induced IFN-gamma production [score: 1 (0%)]

IL-12 is an important cytokine involved in production of IFN-gamma by T cells and NK cells, and plays an important role in T-helper ...

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