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Regulatory Processes
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Protein Regulatory Pathways
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Transcription_CREB pathway [score: 1 (0%)]
Extracellular stimuli elicit changes in gene expression in target cells by activating
intracellular protein kinase cascades that phosphorylate transcription factors within the
nucleus. One of the best characterized stimulus-induced transcription factors is cyclic
AMP (cAMP) responsive element binding ...
Transcription_Receptor-mediated HIF regulation [score: 1 (0%)]
Insulin and Insulin-like growth factor 1
(IGF-1) induce Hypoxia-inducible factor 1 alpha subunit
(HIF1A) [1], [2] and HIF-induced
Vascular endothelial growth factor (VEGF) expression [1], ...
Immune response _IFN gamma signaling pathway [score: 1 (0%)]
Interferons (IFNs) are pleiotropic cytokines that mediate anti-viral responses,
inhibit proliferation and participate in immune surveillance and tumor suppression by
inducing the transcription of a number of IFN-stimulated genes. The IFN family includes
two main classes of related cytokines, type ...
Development_EGFR signaling pathway [score: 1 (0%)]
Epidermal growth factor receptor (EGFR) belongs to the
ERBB family of receptor tyrosine kinases that contains four
closely related members EGFR and ERBB2-4. They couple the
binding of the extracellular growth factor ligands to intracellular signaling pathways
that regulate diverse ...
Development_VEGF-family signaling [score: 1 (0%)]
The vascular endothelial growth factor (VEGF) family of ligands and receptors is
crucial for vascular development and neovascularization in physiological and pathological
processes in both embryos, and in adults [1].
VEGFs belong to a family of homodimeric glycoproteins ...
Development_A2B receptor: action via G-protein alpha s [score: 1 (0%)]
Adenosine A2B
receptor influences cell differentiation and proliferation.
A2B receptors are G-protein-coupled receptors coupling to
classical second messenger pathways, such as modulation of Cyclic Adenosine
3',5'-phosphate (cAMP)
production or the Phospholipase ...
Development_VEGF signaling via VEGFR2 - generic cascades [score: 1 (0%)]
VEGF family of ligands and receptors is crucial for vascular development and
neovascularization in physiological and pathological processes in both embryo and adult.
VEGFR-2 is a high-affinity receptor for
VEGF-A. Activated VEGFR-2 can
activate p38 MAPK, PI3K reg class
IA/ ...
Development_VEGF signaling and activation [score: 1 (0%)]
The vascular endothelial growth factor (VEGF) family of ligands and receptors is
crucial for vascular development and neovascularization in physiological and pathological
processes in both embryo and adult [1]. VEGFs denote a family of homodimeric
glycoproteins that currently ...
Development_Prolactin receptor signaling [score: 1 (0%)]
Prolactin is a polypeptide hormone secreted by the
pituitary gland and to a lesser extent by numerous extrapituitary tissues. This hormone
affects a great amount of physiological processes [1]. Numerous biological
functions have been attributed to this hormone's ...
Translation_Insulin regulation of translation [score: 1 (0%)]
Insulin plays an important role in the overall regulation
of protein synthesis. Protein synthesis (mRNA translation) is conventionally divided into
three stages: initiation, elongation and termination. Both initiation and elongation can
be controlled by Insulin.
Insulin ...
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