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Regulatory Processes
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Protein Regulatory Pathways
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Signal transduction_PTEN pathway [score: 1 (0%)]
Phosphatase and tensin homolog (PTEN) is a known tumor
suppressor. It inhibits growth factor-induced cell proliferation, division and regulates
Integrin-mediated cell adhesion and survival [1].
PTEN antagonizes Phosphoinositide-3-kinase
(PI3K), ...
Cell adhesion_PLAU signaling [score: 1 (0%)]
The binding of Plasminogen activator, urokinase (PLAU
(UPA)) to its glycosyl-phosphatidyl-inositol (GPI) anchored Plasminogen
activator, urokinase receptor (PLAUR (UPAR) (uPAR)) mediates
a variety of functions including vascular homeostasis, inflammation and tissue repair
[1].
PLAU ...
Development_EGFR signaling via PIP3 [score: 1 (0%)]
The Epidermal growth factor receptor (EGFR) belongs to
the ERBB family of receptor tyrosine kinases, which consists of four closely related
members: EGFR and v-erb-b2 erythroblastic leukemia viral
oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
(ERBB2), ERBB3 ...
Development_EGFR signaling via small GTPases [score: 1 (0%)]
The Epidermal growth factor receptor (EGFR) belongs to
the ERBB family of receptor tyrosine kinases, which consists of four closely related
members: EGFR and v-erb-b2 erythroblastic leukemia viral
oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
(ERBB2), ERBB3 ...
Cell adhesion_Integrin inside-out signaling [score: 1 (0%)]
The integrin family of transmembrane adhesion receptors mediates both cell-cell and
cell- extracellular matrix (ECM) adhesion. One important, rapid and reversible mechanism
for regulating adhesion is increasing the affinity of integrin receptors for their
extracellular ligands (integrin activation). ...
Translation_Insulin regulation of translation [score: 1 (0%)]
Insulin plays an important role in the overall regulation
of protein synthesis. Protein synthesis (mRNA translation) is conventionally divided into
three stages: initiation, elongation and termination. Both initiation and elongation can
be controlled by Insulin.
Insulin ...
Regulation of lipid metabolism_Insulin signaling:generic cascades [score: 1 (0%)]
The binding of Insulin to the extracellular domain of the
Insulin receptor results in the activation of the tyrosine
kinase activity of the receptor. Following the autophosphorylation, the
Insulin receptor phosphorylates a number of intracellular
substrates to initiate a series ...
Immune response _CCR3 signaling in eosinophils [score: 1 (0%)]
Human eosinophils are key effector cells implicated in a number of chronic
inflammatory reactions, associated with bronchial asthma, allergic-inflammatory diseases
and parasitic infections. Chemoattractants/chemokines, generated at the affected sites,
promote migration of eosinophils from vasculature ...
Development_EPO-induced MAPK pathway [score: 1 (0%)]
Erythropoiesis is the main pathway of pluripotent hematopoietic stem cell development
into mature end stage cells. Erythropoietin (Epo) is a major
lineage-specific hematopoietic growth factor required for survival, proliferation and
differentiation of committed erythroid progenitor cells [
Translation_Non-genomic (rapid) action of Androgen Receptor [score: 1 (0%)]
Androgen is the active metabolic product, 5alpha-Dihydrotestosterone
(DHT), which is produced from the transformation of
Testosterone catalyzed by the Steroid-5-alpha-reductase,
alpha polypeptides 1 and 2 (S5AR1 and
S5AR2) [1], [2]. ...
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