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Development_EDNRB signaling [score: 1 (0%)]
Endothelin receptor type B (EDNRB) belongs to the guanine
nucleotide binding protein (G-protein) coupled receptor family.
Endothelin-1 is most investigated physiological ligand of
EDNRB [1]. EDNRB
binds to many types of the G-proteins but the ...
Apoptosis and survival_Role of CDK5 in neuronal death and survival [score: 1 (0%)]
Cyclin-dependent kinase 5 (CDK5) is a member of the small
serine/threonine cyclin-dependent kinase (CDK) family.
The best known role of CDK5 is its regulatoin of the
cytoskeleton architecture of the central nervous system (CNS). There is also some
evidence that links CDK5 ...
Development_Activation of ERK by Alpha-1 adrenergic receptors [score: 1 (0%)]
Subtype alpha-1 adrenergic receptors consists of Alpha-1A adrenergic
receptor, Alpha-1B adrenergic receptor and
Alpha-1D adrenergic receptor. They participate in many
physiological processes via different pathways. One of the best studied alpha-1
adrenergic receptors-stimulated ...
Development_Alpha-2 adrenergic receptor activation of ERK [score: 1 (0%)]
Alpha-2A adrenergic receptor, Alpha-2B
adrenergic receptor, and Alpha-2C-1 adrenergic
receptor participate in activation of Mitogen-activated protein kinases 1
and 3 (ERK1/2) via different ways [1].
Alpha-2A adrenergic receptor ...
Mucin expression in CF via TLRs, EGFR signaling pathways [score: 1 (0%)]
Cystic Fibrosis (CF) is a potentially lethal genetic disease that typically results in
the development of bronchial inflammation, bronchiectasis, the progressive loss of lung
function and ultimately death [1].
CF was initially called "mucoviscidosis" because of ...
Inhibitory action of Lipoxins on neutrophil migration [score: 1 (0%)]
Deregulated neutrophilic inflammation and chronic infection lead to progressive
destruction of the airways in cystic fibrosis (CF). In normal tissues, lipoxins are
endogenous anti-inflammatory lipid mediators in regulation of neutrophilic inflammation
[1]. In CF, production ...
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