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Transcription_CREB pathway [score: 1 (0%)]
CREB signaling pathway

Extracellular stimuli elicit changes in gene expression in target cells by activating intracellular protein kinase cascades that phosphorylate transcription factors within the nucleus. One of the best characterized stimulus-induced transcription factors ...

Transcription_Receptor-mediated HIF regulation [score: 1 (0%)]

Receptor-mediated HIF regulation

Insulin and Insulin-like growth factor 1 (IGF-1) induce Hypoxia-inducible factor 1 alpha subunit (HIF1A) [1], [2] ...

Immune response _IFN gamma signaling pathway [score: 1 (0%)]

Interferon-gamma signaling

Interferons (IFNs) are pleiotropic cytokines that mediate anti-viral responses, inhibit proliferation and participate in immune surveillance and tumor suppression by inducing the ...

Immune response_T cell receptor signaling pathway [score: 1 (0%)]

T cell receptor signaling pathway

T cell receptors (TCR) play a key role in functioning of T cells and formation of the immunological synapse. It provides connection between T cell and the antigen-presenting ...

Development_Angiotensin signaling via PYK2 [score: 1 (0%)]

Angiotensin activation of MAPKs via Pyk2

Angiotensin II, a major effector peptide of the renin-angiotensin system, is believed to play a critical role in the pathogenesis of cardiovascular remodeling associated with hypertension, heart failure, and atherosclerosis. [1]

Angiotensin ...

Development_EGFR signaling pathway [score: 1 (0%)]
EGFR signaling pathway

Epidermal growth factor receptor (EGFR) belongs to the ERBB family of receptor tyrosine kinases that contains four closely related members EGFR and ERBB2-4. They couple ...

Development_VEGF-family signaling [score: 1 (0%)]

VEGF-family signaling

The vascular endothelial growth factor (VEGF) family of ligands and receptors is crucial for vascular development and neovascularization in physiological and pathological processes ...

Signal transduction_Erk Interactions: Inhibition of Erk [score: 1 (0%)]

Erk Interactions: Inhibition of Erk

Mitogen-activated protein kinase (MAPK) pathways regulate a variety of physiological processes, such as cell growth, differentiation, and apoptotic cell death. To date, ...

Signal transduction_Activation of PKC via G-Protein coupled receptor [score: 1 (0%)]

PKC family signaling

The family of Protein kinase C (PKC) contains 3 functional protein types, "conventional" PKC-alpha, PKC-beta, and PKC-gamma that are activated by calcium and Diacylglycerol (DAG), "novel" PKC-delta, PKC-epsilon, PKC-eta, ...

Development_A2B receptor: action via G-protein alpha s [score: 1 (0%)]

Adenosine A2B receptor signaling

Adenosine A2B receptor influences cell differentiation and proliferation. A2B receptors are G-protein-coupled receptors coupling to classical second ...

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