Extracellular stimuli elicit changes in gene expression in target cells by activating intracellular protein kinase cascades that phosphorylate transcription factors within the nucleus. One of the best characterized stimulus-induced transcription factors ...
Angiotensin II, a major effector peptide of the
renin-angiotensin system, is believed to play a critical role in the pathogenesis of
cardiovascular remodeling associated with hypertension, heart failure, and
The family of Protein kinase C (PKC)
contains 3 functional protein types, "conventional"
PKC-alpha, PKC-beta, and
PKC-gamma that are activated by calcium and Diacylglycerol
(DAG), "novel" PKC-delta,
PKC-epsilon, PKC-eta, ...