Endogenous and exogenous estrogens undergo oxidative metabolism by hepatic microsomal
cytochrome P-450. Aromatic hydroxylation at either the C2 or C4 position is a major route
of Estradiol metabolism in humans and other mammals,
although there is less 4-hydroxylation ...
D-Glucose is the major energy source for mammalian cells
as well as an important substrate for protein and lipid synthesis. Mammalian cells take
up D-Glucose from extracellular fluid into the cell through
two families of structurally ...
Metabolism and binding studies with 2-Naphthylamine and
many other arylamines have shown cytochrome P-450 catalysed N-hydroxylation to be a
critical step in the activation of these compounds. Followed by glucuronidation and
excretion of ...
Toxicity of Naphthalene in cell culture and animal models has to do with metabolisation of this compound by cytochrome P450 monooxygenases. Deactivation of Naphthalene involves epoxidation followed by glutathione conjugation and mercapturic ...
Lipases are water-soluble enzymes that catalyze the hydrolysis of ester chemical bonds
in water-insoluble lipid substrates. Lipases are widely distributed in animals, plants
and prokaryotes. The lipase family consists of triglyceride lipases, phospholipases and