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Protein Regulatory Pathways
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Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins [score: 1 (0%)]
Apoptosis is an evolutionarily conserved type of programmed cell death essential for
development, homeostasis, and self-defense against infection. It can be triggered by a
number of factors including UV- or gamma-irradiation, chemotherapeutic drugs, or
signaling by death receptors. There are two ...
Apoptosis and survival_Caspase cascade [score: 1 (0%)]
Caspases are the central components of the apoptotic response. The apoptotic caspases
are generally divided into two classes: the initiator caspases, which include
caspase-2, -8,
-9 and -10 and the effector
caspases, which include caspases-3,
-6 and -7. ...
Transcription_P53 signaling pathway [score: 1 (0%)]
The Tumor protein p53 (p53) plays a critical role in
safeguarding the integrity of the genome. Upon activation,
p53 binds to the enhancer/promoter elements of downstream
target genes and regulates their transcription, through which it initiates cellular
programs that account for most ...
DNA damage_ATM/ATR regulation of G1/S checkpoint [score: 1 (0%)]
DNA damage checkpoints are biochemical pathways that delay or arrest the cell cycle
progression in response to the DNA damage. All eukaryotic cells have four phases within
the cell cycle, G1, S, G2, and M, and one outside, G0 [1].
The G1/S checkpoint prevents cells ...
DNA damage_Role of Brca1 and Brca2 in DNA repair [score: 1 (0%)]
DNA damage-dependent activation of the breast and ovarian cancer susceptibility
protein 1 (Brca1) occurs via activation of ataxia
telangiectasia mutated serine-protein kinase
(ATM) [1] or ataxia
telangiectasia and Rad3 related protein kinase
(ATR) ...
Apoptosis and survival_BAD phosphorylation [score: 1 (0%)]
BAD is a member of the BCL-2 family. BCL-2 family members
are regulators of the programmed cell death pathways.
BAD induces apoptosis by inhibiting antiapoptotic
BCL-2-family members - BCL-x,
Bcl-2, thereby allowing two other pro-apoptotic proteins,
BAK ...
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