Apoptosis is an evolutionarily conserved type of programmed cell death essential for
development, homeostasis, and self-defense against infection. It can be triggered by a
number of factors including UV- or gamma-irradiation, chemotherapeutic ...
Caspases are the central components of the apoptotic response. The apoptotic caspases
are generally divided into two classes: the initiator caspases, which include
-9 and -10 and the effector
caspases, which include ...
The Tumor protein p53 (p53) plays a critical role in
safeguarding the integrity of the genome. Upon activation,
p53 binds to the enhancer/promoter elements of downstream
target genes and regulates their transcription, through which it initiates ...
DNA damage checkpoints are biochemical pathways that delay or arrest the cell cycle
progression in response to the DNA damage. All eukaryotic cells have four phases within
the cell cycle, G1, S, G2, and M, and one outside, ...
DNA damage-dependent activation of the breast and ovarian cancer susceptibility
protein 1 (Brca1) occurs via activation of ataxia
telangiectasia mutated serine-protein kinase(ATM)  or ataxia