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2-Naphthylamine and 2-Nitronaphtalene metabolism [score: 1 (0%)]
Metabolism and binding studies with 2-Naphthylamine and
many other arylamines have shown cytochrome P-450 catalysed N-hydroxylation to be a
critical step in the activation of these compounds. Followed by glucuronidation and
excretion of the glucuronides via the kidney, this reaction can account ...
Development_Alpha-2 adrenergic receptor activation of ERK [score: 1 (0%)]
Alpha-2A adrenergic receptor, Alpha-2B
adrenergic receptor, and Alpha-2C-1 adrenergic
receptor participate in activation of Mitogen-activated protein kinases 1
and 3 (ERK1/2) via different ways [1].
Alpha-2A adrenergic receptor ...
Naphthalene metabolism [score: 1 (0%)]
Toxicity of Naphthalene in cell culture and animal models
has to do with metabolisation of this compound by cytochrome P450 monooxygenases.
Deactivation of Naphthalene involves epoxidation followed by
glutathione conjugation and mercapturic acid formation [1].
Naphthalene ...
Role of CDK5 in neuronal cell function [score: 1 (0%)]
Cyclin-dependent kinase 5 (CDK5) is a member of the small
serine/threonine cyclin-dependent kinase family.
CDK5 is abundantly expressed in the adult brain.
Moreover, it is present in subcellular fractions enriched for synaptic membranes, and
localize to pre- and postsynaptic ...
Lipase family functions [score: 1 (0%)]
Lipases are water-soluble enzymes that catalyze the hydrolysis of ester chemical bonds
in water-insoluble lipid substrates. Lipases are widely distributed in animals, plants
and prokaryotes. The lipase family consists of triglyceride lipases, phospholipases and
sphingomyelinases. By the place of ...
Manganese, Calcium and Iron-regulated proteins [score: 1 (0%)]
Proteins, regulated by binding of inorganic ions, are very important for different
aspects of cell functioning.
There is a wide variety of Calcium, Manganese and Iron-regulated proteins inside and
out of the cells.
Binding of Ca('2+) extracellular region to receptors of
L-Glutamic ...
Fructose metabolism [score: 1 (0%)]
D-Sucrose and Glycogen are
the primary sources of D-fructose synthesis.
D-Sucrose is hydrolyzed to
D-fructose and D-Glucose by
Maltase-glucoamylase (MGAM) and Sucrase-isomaltase
(SUIS) [1]. Ketohexokinase
(KHK) ...
L-Arginine, L-Alanine, L-Aspartic acid and Creatine metabolism [score: 1 (0%)]
Metabolism of L-Arginine, L-Alanine, L-Aspartic acid and Creatine is part of the urea
cycle.
The urea cycle represents the set of conversion reactions of ammonia, a toxic product
of oxidative deamination reactions, into Urea, a relatively
nontoxic excretion product of nitrogen metabolism ...
Selected targets of C/EBP [score: 1 (0%)]
CCAAT/enhancer binding proteins (C/EBP) are a group of
bZIP transcription factors, consisting of C/EBPalpha,
beta, delta,
epsilon, gamma and
zeta, which can bind as homodimers to certain promoters and
enhancers. C/EBP is important in the regulation ...
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