Protein biosynthesis is largely governed by a cohort of Eukaryotic translation
initiation factors (eIF) that mediate specific steps in the
initiation process. A rate-limiting step in translation
initiation involves formation of the eIF4F complex that
Eukaryotic translation initiation factors (eIF2) is a
G-protein that is composed of 3 non-identical subunits,
and eIF2S3, and catalyzes the first regulated
step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S
RAC-alpha serine/threonine kinases (AKTs) are crucial
mediators of various cellular process, such as apoptosis, regulation of cell cycle,
protein synthesis and regulation of metabolism. The activity of
AKT is modulated by various proteins, including
Insulin plays an important role in the overall regulation
of protein synthesis. Protein synthesis (mRNA translation) is conventionally divided into
three stages: initiation, elongation and termination. Both initiation and elongation can
be controlled by Insulin.
The binding of Insulin to the extracellular domain of the
Insulin receptor results in the activation of the tyrosine
kinase activity of the receptor. Following the autophosphorylation, the
Insulin receptor phosphorylates a number of intracellular
substrates to initiate a series ...
Androgen is the active metabolic product, 5alpha-Dihydrotestosterone
(DHT), which is produced from the transformation of
Testosterone catalyzed by the Steroid-5-alpha-reductase,
alpha polypeptides 1 and 2 (S5AR1 and
S5AR2) , . ...
Sp1 transcription factor (SP1) is a transcription factor
involved in gene expression in the early development of an organism. It belongs to the
Sp/KLF family of transcription factors. The SP1
transcription factor contains a zinc finger protein motif, by which it binds directly to
Hepatocyte nuclear factors (HNFs) are a group of phylogenetically unrelated
transcription factors that regulate the transcription of a diverse group of genes.
Hepatocyte nuclear factors are expressed predominately in the liver. However, HNFs are
also expressed and play important roles in a number ...