Cytoskeleton of most eukaryotic cells consists of three distinct, yet interconnected,
filament systems: actin filaments,
microtubules and intermediate filaments (IF). IF network is
critically involved in cell shape control and imparts intracellular mechanical
Prostaglandin E2 (PGE2)is a
crucial mediator of inflammatory pain sensitization. Prostaglandin
E2 is produced in response to inflammation both in peripheral inflamed
tissues and in the spinal cord .
Glutamic acid is the major excitatory neurotransmitter in
the brain. The excitation of medium spiny neurons is regulated by a balance of
glutamatergic inputs from corticostriatal and thalamostriatal pathways and dopaminergic
inputs from the nigrostriatal pathway .
Nicotinic acetylcholine receptors (nAChR) are cholinergic
receptors that form ligand-gated ion channels in the plasma membranes of certain neurons
and on the postsynaptic side of the neuromuscular junctions. As ionotropic receptors,
nAChR are directly linked to ion channels and do not ...