Interleukin-6 (IL-6) is a pleiotropic cytokine produced by various types of lymphoid and nonlymphoid cells, such as T cells, B cells, monocytes, fibroblasts, keratinocytes, endothelial cells, mesangial cells and several tumor cells. IL-6 provokes a broad range of cellular and physiological responses, ...

Deregulated neutrophilic inflammation and chronic infection lead to progressive destruction of the airways in cystic fibrosis (CF). In normal tissues, lipoxins are endogenous anti-inflammatory lipid mediators in regulation of neutrophilic inflammation [1]. In CF, production ...