The Nuclear factor kappa B (NF-kB) plays a crucial role
in immune and inflammatory responses through the regulation of genes encoding
pro-inflammatory cytokines, adhesion molecules, chemokines, growth factors and inducible
enzymes. Transcription factors ...
The tumor necrosis factor (TNF-alpha) is a potent cytokine produced by many cell types, including macrophages, monocytes, lymphocytes, keratinocytes and fibroblasts, in response to inflammation, infection, injury and other environmental challenges. ...
The Mitogen-activated protein kinases 8-10
(JNK(MAPK8-10)) belong to a sub-group of evolutionarily
conserved mitogen-activated protein kinases (MAPK) activated primarily by cytokines,
growth factors and by exposure to environmental stress. JNK(MAPK8-10)