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Transcription_NF-kB signaling pathway [score: 1 (0%)]
NF-kB signaling pathway
The Nuclear factor kappa B (
NF-kB) plays a crucial role in immune
and inflammatory responses through the regulation of genes encoding
pro-inflammatory cytokines, adhesion molecules, ...
Apoptosis and survival_TNFR1 signaling pathway [score: 1 (0%)]
Role TNF-alpha in apoptosis
The tumor necrosis factor (
TNF-alpha) is a potent cytokine
produced by many cell types, including macrophages, monocytes,
lymphocytes, keratinocytes and fibroblasts, in response ...
Immune response_Alternative complement pathway [score: 1 (0%)]
Alternative complement pathway
Complement system is a major effector of humoral branch of the immune
system, acting to protect the host from microorganisms, such as bacteria.
Complement components ...
Immune response_IL-6 signaling pathway [score: 1 (0%)]
IL-6 signaling pathway
IL-6) is a pleiotropic cytokine produced by
various types of lymphoid and nonlymphoid cells, such as T cells, B
cells, monocytes, fibroblasts, keratinocytes, ...
Immune response_MIF in innate immunity response [score: 1 (0%)]
MIF in innate immunity response
The cytokine Macrophage migration inhibitory factor (
MIF) is an
integral mediator of the innate immune system. Monocytes, macrophages
and lymphocytes constitutively ...
Signal transduction_JNK pathway [score: 1 (0%)]
The Mitogen-activated protein kinases 8-10
JNK(MAPK8-10)) belong to a sub-group of evolutionarily
conserved mitogen-activated protein kinases (MAPK) activated primarily by cytokines,
growth factors and by exposure to environmental stress. JNK(MAPK8-10)
Transcription_PPAR Pathway [score: 1 (0%)]
Peroxisome Proliferator-Activated Receptors
(PPAR) are ligand-inducible transcription factors that belong to the nuclear hormone receptor superfamily. The PPAR group consists of three types: PPAR-alpha, PPAR-beta(delta) and PPAR-gamma. ...
Immune response_TLR2 and TLR4 signaling pathways [score: 1 (0%)]
TLR2 and TLR4 signaling pathways
TLR2 and TLR4 induce MyD88/ IRAK/ TRAF6-dependent
pathway in target cells, leading to activation of transcription factors NF-kB, ...
Immune response_IL-1 signaling pathway [score: 1 (0%)]
IL-1 signaling pathway
Interleukin-1 (IL-1) is a proinflammatory cytokine produced by activated
macrophages, endothelial cells, B cells and fibroblasts. IL-1 stimulates
a broad spectrum of immune and inflammatory ...
Immune response_Lectin induced complement pathway [score: 1 (0%)]
Lectin induced complement pathway
The complement system is the major effector of the humoral branch of the
immune system, acting to protect the host from microorganisms such as