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Immune response_IL-2 activation and signaling pathway [score: 1 (0%)]
Interleukin-2 (IL-2) is a T-Cell-derived cytokine
important in the regulation of growth and differentiation of T-Cells, B-Cells, natural
killer cells, glioma cells, and cells of the monocyte lineage.
IL-2 signaling is mediated by a multichain
IL-2 receptor complex consisting ...
Immune response_IL-4 signaling pathway [score: 1 (0%)]
Interleukin-4 (IL-4) is a T cell derived multifunctional
cytokine that plays a critical role in the regulation of immune responses.
IL-4 induces Th2 (T helper 2) differentiation, causes
macrophage suppression, and stimulates B cell production of Immunoglobulins E, G1 and G4
(IgE, ...
Immune response _IFN gamma signaling pathway [score: 1 (0%)]
Interferons (IFNs) are pleiotropic cytokines that mediate anti-viral responses,
inhibit proliferation and participate in immune surveillance and tumor suppression by
inducing the transcription of a number of IFN-stimulated genes. The IFN family includes
two main classes of related cytokines, type ...
Immune response_T cell receptor signaling pathway [score: 1 (0%)]
T cell receptors (TCR) play a key role in functioning of
T cells and formation of the immunological synapse. It provides connection between T cell
and the antigen-presenting cell (APC) [1]. TCRs are composed of
ligand-binding subunits, the alpha and beta chains, ...
Immune response_MIF-JAB1 signaling [score: 1 (0%)]
Macrophage migration inhibitory factor (MIF) is a
pluripotent cytokine involved in inflammation and immune responses as well as in growth
factor-dependent cell proliferation, cell cycle, angiogenesis, and tumorigenesis [1], [2], [3], ...
Immune response_IL-22 signaling pathway [score: 1 (0%)]
Interleukin-22 (IL-22) is a member of the IL-10 family of
cytokines. The major sources of IL-22 are activated T cells,
especially upon type 1 polarization, and natural killer (NK) cells [1], [2].
IL-22 acts via a ...
Immune response_IL-9 signaling pathway [score: 1 (0%)]
Interleukin-9 (IL-9) is a multifunctional cytokine
secreted by T helper 2 (Th2) lymphocytes. IL-9 exerts
various effects on a variety of cell types associated with allergic inflammation.
IL-9 stimulates the growth and proliferation of T cells,
enhances the production of IgE from ...
Immune response_IL-10 signaling pathway [score: 1 (0%)]
Interleukin-10 (IL-10) is a pleiotropic cytokine with
important immunoregulatory functions. Its actions influence activities of many of the
cell-types in the immune system. It is also a cytokine with potent anti-inflammatory
properties: it represses the expression of inflammatory cytokines, ...
Immune response_Function of MEF2 in T lymphocytes [score: 1 (0%)]
Myocyte enhancer factors 2 (MEF2) is a family of
muscle-enriched transcription factors that have an essential role in myogenesis. In
addition, MEF2 is also expressed at high levels in neurons
and lymphocytes, where it serves as a regulator of neuronal and immune cell
differentiation ...
Immune response_BCR pathway [score: 1 (0%)]
The BCR (B-Cell antigen Receptor) plays a critical role in development, survival, and
activation of B lymphocytes. The BCR is composed of membrane immunoglobulin
(IgM) molecules associated with CD79a molecule,
immunoglobulin-associated alpha - CD79b molecule, immunoglobulin-associated beta
heterodimers ...
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