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Regulatory Processes
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Development_Neurotrophin family signaling [score: 1 (0%)]

Factors of the neurotrophin family (NGF, BDNF and neurotrophins NT-3 and NT-4/5), promote neuronal survival or death. The best characterized receptors for these trophic factors are the tropomyosin-related tyrosine kinase receptors TrkA, TrkB, and TrkC, ...

Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway [score: 1 (0%)]

Parkin is E3-ubiquitin-protein ligase that ubiquitinates itself and specific substrate proteins playing a protective role by sequestering misfolded proteins [1].

E3 ligases are part of the cellular machinery that tags proteins with ubiquitin, thereby targeting ...

Development_Dopamine D2 receptor transactivation of EGFR [score: 1 (0%)]

Dopamine is a major transmitter and neuromodulator in the CNS. This transmitter mediates its signaling through GPCRs of which the Dopamine D2 receptor class of ...

Regulation and function of Amyloid proteins [score: 1 (0%)]

Amyloid precursor protein (APP) was initially detected in cells of the central nervous system and is considered to be involved in the pathogenesis of Alzheimer's disease [1]. Since then, APP has been found in peripheral organs where it plays a variety of ...

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