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Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway [score: 1 (0%)]
Parkin is E3-ubiquitin-protein ligase that ubiquitinates
itself and specific substrate proteins playing a protective role by sequestering
misfolded proteins [1].
E3 ligases are part of the cellular machinery that tags proteins with ubiquitin,
thereby targeting ...
Development_MAG-dependent inhibition of neurite outgrowth [score: 1 (0%)]
Neurotrophins are key regulators of the fate and shape of neuronal cells. They act as
guidance cues for growth cones by remodeling actin cytoskeleton. Neurotrophins
(NGF, BDNF,
NT-3 and NT-4/5) bind to two
structurally unrelated receptors, tyrosine kinase Trk receptors
(TrkA, ...
Development_Slit-Robo signaling [score: 1 (0%)]
Attractive and repulsive receptors regulate cell motility and attachment in axon
guidance, vascular growth, immune cell regulation and tumor progression. There is strong
evidence that development of the nervous and vascular systems is controlled by common
cues.
Semaphorins, Ephrins, SLITs ...
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