Results

Retinoid receptors are asymmetrically oriented Retinoic acid receptor (RAR)/ Retinoid X receptor (RXR) heterodimers that bind to specific DNA sequences or Retinoic acid response elements (RAREs) in the promoters ...

Transcription_CREB pathway [score: 1 (0%)]

CREB signaling pathway

Extracellular stimuli elicit changes in gene expression in target cells by activating intracellular protein kinase cascades that phosphorylate transcription factors within the nucleus. ...

Transcription_NF-kB signaling pathway [score: 1 (0%)]

NF-kB signaling pathway

The Nuclear factor kappa B (NF-kB) plays a crucial role in immune and inflammatory responses through the regulation of genes encoding pro-inflammatory cytokines, adhesion molecules, chemokines, growth factors and inducible enzymes. Transcription factors ...

Transcription_P53 signaling pathway [score: 1 (0%)]

p53 signaling pathway

The Tumor protein p53 (p53) plays a critical role in safeguarding the integrity of the genome. Upon activation, p53 binds to the enhancer/promoter elements of downstream target genes and regulates their transcription, through which it initiates ...

Transcription_Receptor-mediated HIF regulation [score: 1 (0%)]

Receptor-mediated HIF regulation

Insulin and Insulin-like growth factor 1 (IGF-1) induce Hypoxia-inducible factor 1 alpha subunit (HIF1A) [1], [2] ...

Development_Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis [score: 1 (0%)]

Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

There are two families of transcription factors that play pivotal roles during mammalian skeletal muscle differentiation. One of them includes MyoD family proteins (also called myogenic regulatory ...

Development_NOTCH1-mediated pathway for NF-KB activity modulation [score: 1 (0%)]

NOTCH1-mediated pathway for NF-KB activity modulation

Interleukin 1 (IL-1) activates Nuclear factor of kappa light polypeptide gene enhancer in B-cells (NF-KB) via Interleukin-1 receptor-associated kinase (IRAK) and Mitogen-activated protein kinase kinase kinase ...

Immune response_Function of MEF2 in T lymphocytes [score: 1 (0%)]

Function of MEF2 in T lymphocytes.

Myocyte enhancer factors 2 (MEF2) is a family of muscle-enriched transcription factors that have an essential role in myogenesis. In addition, MEF2 is also expressed at high levels in neurons and lymphocytes, where it serves as a regulator ...

Cell cycle_Regulation of G1/S transition (part 1) [score: 1 (0%)]

Regulation of G1/S transition (part 1)

DNA damage checkpoints are biochemical pathways that delay or halt cell cycle progression in response to DNA damage. Cell cycle proceeds in four phases in all somatic eukaryotic cells, G1, S, G2, and M, and one outside ...

Transcription_PPAR Pathway [score: 1 (0%)]

PPAR Pathway

Peroxisome Proliferator-Activated Receptors (PPAR) are ligand-inducible transcription factors that belong to the nuclear hormone receptor superfamily. The PPAR group consists of ...

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