VEGF family of ligands and receptors is crucial for vascular development and neovascularization in physiological and pathological processes in both embryo and adult. VEGFR-2 is a high-affinity receptor for VEGF-A. Activated VEGFR-2 can activate p38 MAPK, PI3K reg class IA/ ...

Endothelin receptor type B (EDNRB) belongs to the guanine nucleotide binding protein (G-protein) coupled receptor family. Endothelin-1 is most investigated physiological ligand of EDNRB [1]. EDNRB binds to many types of the G-proteins but the ...