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Transcription_Receptor-mediated HIF regulation [score: 1 (0%)]
Insulin and Insulin-like growth factor 1
(IGF-1) induce Hypoxia-inducible factor 1 alpha subunit
(HIF1A) [1], [2] and HIF-induced
Vascular endothelial growth factor (VEGF) expression [1], ...
Development_Angiotensin signaling via PYK2 [score: 1 (0%)]
Angiotensin II, a major effector peptide of the
renin-angiotensin system, is believed to play a critical role in the pathogenesis of
cardiovascular remodeling associated with hypertension, heart failure, and
atherosclerosis. [1]
Angiotensin II receptor, ...
Development_FGFR signaling pathway [score: 1 (0%)]
Fibroblast growth factor 2 (FGF2) has been implicated in
diverse cellular processes, including apoptosis, cell survival, chemotaxis, cell
adhesion, migration, differentiation, and proliferation [1].
FGF2 induces biological responses by binding to ...
Development_VEGF-family signaling [score: 1 (0%)]
The vascular endothelial growth factor (VEGF) family of ligands and receptors is
crucial for vascular development and neovascularization in physiological and pathological
processes in both embryos, and in adults [1].
VEGFs belong to a family of homodimeric glycoproteins ...
Development_Notch Signaling Pathway [score: 1 (0%)]
Notch homolog 1 translocation-associated (NOTCH1) is
synthesized as NOTCH1 precursor, which is cleaved by
Furin to NOTCH1
receptor form. NOTCH1 receptor
is activated by Jagged [1]. O-fucosylpeptide
3-beta-N-acetylglucosaminyltransferase ...
Development_NOTCH1-mediated pathway for NF-KB activity modulation [score: 1 (0%)]
Interleukin 1 (IL-1) activates Nuclear factor of kappa
light polypeptide gene enhancer in B-cells (NF-KB) via
Interleukin-1 receptor-associated kinase (IRAK) and
Mitogen-activated protein kinase kinase kinase 1
(MEKK1(MAP3K1))-dependent inhibition of nuclear factor of
kappa ...
Development_VEGF signaling via VEGFR2 - generic cascades [score: 1 (0%)]
VEGF family of ligands and receptors is crucial for vascular development and
neovascularization in physiological and pathological processes in both embryo and adult.
VEGFR-2 is a high-affinity receptor for
VEGF-A. Activated VEGFR-2 can
activate p38 MAPK, PI3K reg class
IA/ ...
Development_VEGF signaling and activation [score: 1 (0%)]
The vascular endothelial growth factor (VEGF) family of ligands and receptors is
crucial for vascular development and neovascularization in physiological and pathological
processes in both embryo and adult [1]. VEGFs denote a family of homodimeric
glycoproteins that currently ...
Development_Angiotensin signaling via beta-Arrestin [score: 1 (0%)]
Angiotensin II, a major effector peptide of the
renin-angiotensin system, is now believed to play a critical role in the pathogenesis of
cardiovascular remodeling associated with hypertension, heart failure, and
atherosclerosis [1].
Angiotensin II receptor ...
Development_EDNRB signaling [score: 1 (0%)]
Endothelin receptor type B (EDNRB) belongs to the guanine
nucleotide binding protein (G-protein) coupled receptor family.
Endothelin-1 is most investigated physiological ligand of
EDNRB [1]. EDNRB
binds to many types of the G-proteins but the ...
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