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Cytoskeleton remodeling_FAK signaling [score: 1 (0%)]
The biological importance of PTK2 protein tyrosine kinase 2, or Focal
adhesion kinase 1 (FAK1)-mediated signal transduction is
underscored by the fact that this tyrosine kinase plays a fundamental role in embryonic
development, in control of cell migration, cell cycle progression, and in apoptosis.
Binding ...
Development_A2B receptor: action via G-protein alpha s [score: 1 (0%)]
Adenosine A2B
receptor influences cell differentiation and proliferation.
A2B receptors are G-protein-coupled receptors coupling to
classical second messenger pathways, such as modulation of Cyclic Adenosine
3',5'-phosphate (cAMP)
production or the Phospholipase ...
Development_HGF signaling pathway [score: 1 (0%)]
Hepatocyte growth factor/Scatter factor (HGF) is a
multifunctional growth factor which induces cell dissociation, migration, protection from
apoptosis, proliferation and differentiation [1]. Receptor Met
proto-oncogene (HGF receptor (Met))
has tyrosine-kinase ...
Development_IGF-1 receptor signaling [score: 1 (0%)]
The insulin-like growth factor system (IGF system) comprises two receptors:
Insulin-like growth factor 1 receptor (IGF-1 receptor) and
IGF-IIR with their respective ligands: Insulin-like growth factors 1 and 2
(IGF-1 and IGF-2) and six
high-affinity IGF binding proteins (IBP).
The ...
Development_Prolactin receptor signaling [score: 1 (0%)]
Prolactin is a polypeptide hormone secreted by the
pituitary gland and to a lesser extent by numerous extrapituitary tissues. This hormone
affects a great amount of physiological processes [1]. Numerous biological
functions have been attributed to this hormone's ...
Development_A3 receptor signaling [score: 1 (0%)]
Adenosine is a potent biological mediator
that affects numerous cell types including neural cells, platelets, neutrophils and
smooth muscle cells. Currently, four adenosine receptor subtypes have been identified:
A1, A2A, A2B and A3. Adenosine receptors are G-protein-coupled receptors that ...
Development_Ligand-independent activation of ESR1 and ESR2 [score: 1 (0%)]
In addition to the conventional hormone-dependent regulation of activity of Estrogen
receptor alpha and beta (ESR1(nuclear) and
ESR2 respectively), there is a cross-talk between signal transduction
pathways and estrogen receptors [1]. Epidermal growth factor
(EGF), ...
Development_Growth hormone signaling via PI3K/AKT and MAPK cascades [score: 1 (0%)]
Growth hormone (GH or Somatotropin) is a major
growth-promoting and metabolic regulatory hormone. Interaction of
Somatotropin with Growth hormone receptor
(GHR), by virtue of receptor dimerization, causes activation
of GHR associated cytoplasmic tyrosine kinase, Janus kinase ...
Development_Endothelin-1/EDNRA transactivation of EGFR [score: 1 (0%)]
Endothelin-1, a potent endothelium-derived
vasoconstrictor peptide, exerts a growth-promoting effect on vascular smooth muscle
cells, implicating its pathogenic role in vascular remodeling.
Endothelin-1 action is initiated by its binding to
Endothelin receptor type A (EDNRA) ...
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