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Development_HGF signaling pathway [score: 1 (0%)]
Hepatocyte growth factor/Scatter factor (HGF) is a
multifunctional growth factor which induces cell dissociation, migration, protection from
apoptosis, proliferation and differentiation [1]. Receptor Met
proto-oncogene (HGF receptor (Met))
has tyrosine-kinase ...
Development_IGF-1 receptor signaling [score: 1 (0%)]
The insulin-like growth factor system (IGF system) comprises two receptors:
Insulin-like growth factor 1 receptor (IGF-1 receptor) and
IGF-IIR with their respective ligands: Insulin-like growth factors 1 and 2
(IGF-1 and IGF-2) and six
high-affinity IGF binding proteins (IBP).
The ...
Development_Prolactin receptor signaling [score: 1 (0%)]
Prolactin is a polypeptide hormone secreted by the
pituitary gland and to a lesser extent by numerous extrapituitary tissues. This hormone
affects a great amount of physiological processes [1]. Numerous biological
functions have been attributed to this hormone's ...
Transcription_Role of VDR in regulation of genes involved in osteoporosis [score: 1 (0%)]
Osteoporosis is a common disease affecting the majority of older women and a
significant minority of older men. It is defined as the gradual reduction in bone
strength with advancing age, particularly in post-menopause women. Osteoporosis is one of
the major and growing health care problems around ...
Development_Leptin signaling via JAK/STAT and MAPK cascades [score: 1 (0%)]
Leptin, the polypeptide product of the ob
gene, acts on the brain to regulate energy balance. It is hormone,
composed of 167 amino acid residues and produced almost exclusively in adipose tissue.
More-recent studies have revealed additional pleiotrophic functions of
Leptin, including ...
Development_Ligand-independent activation of ESR1 and ESR2 [score: 1 (0%)]
In addition to the conventional hormone-dependent regulation of activity of Estrogen
receptor alpha and beta (ESR1(nuclear) and
ESR2 respectively), there is a cross-talk between signal transduction
pathways and estrogen receptors [1]. Epidermal growth factor
(EGF), ...
Development_Activation of ERK by Alpha-1 adrenergic receptors [score: 1 (0%)]
Subtype alpha-1 adrenergic receptors consists of Alpha-1A adrenergic
receptor, Alpha-1B adrenergic receptor and
Alpha-1D adrenergic receptor. They participate in many
physiological processes via different pathways. One of the best studied alpha-1
adrenergic receptors-stimulated ...
Lipase family functions [score: 1 (0%)]
Lipases are water-soluble enzymes that catalyze the hydrolysis of ester chemical bonds
in water-insoluble lipid substrates. Lipases are widely distributed in animals, plants
and prokaryotes. The lipase family consists of triglyceride lipases, phospholipases and
sphingomyelinases. By the place of ...
Manganese, Calcium and Iron-regulated proteins [score: 1 (0%)]
Proteins, regulated by binding of inorganic ions, are very important for different
aspects of cell functioning.
There is a wide variety of Calcium, Manganese and Iron-regulated proteins inside and
out of the cells.
Binding of Ca('2+) extracellular region to receptors of
L-Glutamic ...
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