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There are two families of transcription factors that play pivotal roles during mammalian skeletal muscle differentiation. One of them includes MyoD family proteins (also called myogenic regulatory factors or MRFs), with four members Myf5, Myogenic differentiation 1 (MYOD), Myogenin (MYOG), ...

Development_FGFR signaling pathway [score: 1 (0%)]

Fibroblast growth factor 2 (FGF2) has been implicated in diverse cellular processes, including apoptosis, cell survival, chemotaxis, cell adhesion, migration, differentiation, and proliferation [1].

FGF2 induces biological responses by binding to ...

Cytoskeleton remodeling_FAK signaling [score: 1 (0%)]

The biological importance of PTK2 protein tyrosine kinase 2, or Focal adhesion kinase 1 (FAK1)-mediated signal transduction is underscored by the fact that this tyrosine kinase plays a fundamental role in embryonic development, in control of cell migration, cell cycle progression, and in apoptosis.

Binding ...

Signal transduction_Activation of PKC via G-Protein coupled receptor [score: 1 (0%)]

The family of Protein kinase C (PKC) contains 3 functional protein types, 'conventional' PKC-alpha, PKC-beta, and PKC-gamma that are activated by calcium and Diacylglycerol (DAG), 'novel' PKC-delta, PKC-epsilon, PKC-eta, and PKC-theta ...

Development_G-Proteins mediated regulation MAPK-ERK signaling [score: 1 (0%)]

Guanine nucleotide binding protein (G-proteins) are heterotrimeric signaling molecules composed of three subunits, alpha, beta, and gamma, which dissociate receptor-induced exchange on the alpha subunit and beta/gamma heterodimer subunit. The G-protein-coupled receptors (GPCRs) initiate diverse ...

Development_TGF-beta receptor signaling [score: 1 (0%)]

Transforming growth factor beta (TGF-beta) signaling controls diverse cellular processes, including cell proliferation, differentiation, adhesion and migration [1], [2], [3].

TGF-beta 1 initiates ...

Development_A2B receptor: action via G-protein alpha s [score: 1 (0%)]

Adenosine A2B receptor influences cell differentiation and proliferation. A2B receptors are G-protein-coupled receptors coupling to classical second messenger pathways, such as modulation of Cyclic Adenosine 3',5'-phosphate (cAMP) production or the Phospholipase ...

Development_Notch Signaling Pathway [score: 1 (0%)]

Notch homolog 1 translocation-associated (NOTCH1) is synthesized as NOTCH1 precursor, which is cleaved by Furin to NOTCH1 receptor form. NOTCH1 receptor is activated by Jagged [1]. O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase ...

Development_HGF signaling pathway [score: 1 (0%)]

Hepatocyte growth factor/Scatter factor (HGF) is a multifunctional growth factor which induces cell dissociation, migration, protection from apoptosis, proliferation and differentiation [1]. Receptor Met proto-oncogene (HGF receptor (Met)) has tyrosine-kinase ...

Development_IGF-1 receptor signaling [score: 1 (0%)]

The insulin-like growth factor system (IGF system) comprises two receptors: Insulin-like growth factor 1 receptor (IGF-1 receptor) and IGF-IIR with their respective ligands: Insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) and six high-affinity IGF binding proteins (IBP).

The ...

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