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Development_FGFR signaling pathway [score: 1 (0%)]
Fibroblast growth factor 2 (FGF2) has been implicated in
diverse cellular processes, including apoptosis, cell survival, chemotaxis, cell
adhesion, migration, differentiation, and proliferation [1].
FGF2 induces biological responses by binding to ...
Cytoskeleton remodeling_FAK signaling [score: 1 (0%)]
The biological importance of PTK2 protein tyrosine kinase 2, or Focal
adhesion kinase 1 (FAK1)-mediated signal transduction is
underscored by the fact that this tyrosine kinase plays a fundamental role in embryonic
development, in control of cell migration, cell cycle progression, and in apoptosis.
Binding ...
Development_G-Proteins mediated regulation MAPK-ERK signaling [score: 1 (0%)]
Guanine nucleotide binding protein
(G-proteins) are heterotrimeric signaling molecules composed
of three subunits, alpha, beta, and gamma, which dissociate receptor-induced exchange on
the alpha subunit and beta/gamma heterodimer subunit. The G-protein-coupled receptors
(GPCRs) initiate diverse ...
Development_TGF-beta receptor signaling [score: 1 (0%)]
Transforming growth factor beta (TGF-beta) signaling
controls diverse cellular processes, including cell proliferation, differentiation,
adhesion and migration [1], [2], [3].
TGF-beta 1 initiates ...
Development_HGF signaling pathway [score: 1 (0%)]
Hepatocyte growth factor/Scatter factor (HGF) is a
multifunctional growth factor which induces cell dissociation, migration, protection from
apoptosis, proliferation and differentiation [1]. Receptor Met
proto-oncogene (HGF receptor (Met))
has tyrosine-kinase ...
Development_IGF-1 receptor signaling [score: 1 (0%)]
The insulin-like growth factor system (IGF system) comprises two receptors:
Insulin-like growth factor 1 receptor (IGF-1 receptor) and
IGF-IIR with their respective ligands: Insulin-like growth factors 1 and 2
(IGF-1 and IGF-2) and six
high-affinity IGF binding proteins (IBP).
The ...
Development_Prolactin receptor signaling [score: 1 (0%)]
Prolactin is a polypeptide hormone secreted by the
pituitary gland and to a lesser extent by numerous extrapituitary tissues. This hormone
affects a great amount of physiological processes [1]. Numerous biological
functions have been attributed to this hormone's ...
Development_A2A receptor signaling [score: 1 (0%)]
Adenosine is a potent biological mediator
that affects numerous cell types, including neuronal cells, platelets, neutrophils and
smooth muscle cells. Currently, four adenosine receptor subtypes have been identified:
A1, A2A, A2B and A3. Adenosine receptors belong to the G-protein-coupled receptor ...
Development_A3 receptor signaling [score: 1 (0%)]
Adenosine is a potent biological mediator
that affects numerous cell types including neural cells, platelets, neutrophils and
smooth muscle cells. Currently, four adenosine receptor subtypes have been identified:
A1, A2A, A2B and A3. Adenosine receptors are G-protein-coupled receptors that ...
Development_Leptin signaling via JAK/STAT and MAPK cascades [score: 1 (0%)]
Leptin, the polypeptide product of the ob
gene, acts on the brain to regulate energy balance. It is hormone,
composed of 167 amino acid residues and produced almost exclusively in adipose tissue.
More-recent studies have revealed additional pleiotrophic functions of
Leptin, including ...
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