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Endothelin-1, a potent endothelium-derived vasoconstrictor peptide, exerts a growth-promoting effect on vascular smooth muscle cells, implicating its pathogenic role in vascular remodeling. Endothelin-1 action is exerted by its binding to Endothelin receptor type A (EDNRA) [

Development_EDNRB signaling [score: 1 (0%)]

Endothelin receptor type B (EDNRB) belongs to the guanine nucleotide binding protein (G-protein) coupled receptor family. Endothelin-1 is most investigated physiological ligand of EDNRB [1]. EDNRB binds to many types of the G-proteins but the ...

Development_Activation of ERK by Alpha-1 adrenergic receptors [score: 1 (0%)]

Subtype alpha-1 adrenergic receptors consists of Alpha-1A adrenergic receptor, Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor. They participate in many physiological processes via different pathways. One of the best studied alpha-1 adrenergic receptors-stimulated ...

Development_Alpha-2 adrenergic receptor activation of ERK [score: 1 (0%)]

Alpha-2A adrenergic receptor, Alpha-2B adrenergic receptor, and Alpha-2C-1 adrenergic receptor participate in activation of Mitogen-activated protein kinases 1 and 3 (ERK1/2) via different ways [1].

Alpha-2A adrenergic receptor ...

Development_Beta-adrenergic receptors signaling via cAMP [score: 1 (0%)]

Beta-1 adrenergic receptor, Beta-2 adrenergic receptor and Beta-3 adrenergic receptor are ...

Development_Dopamine D2 receptor transactivation of EGFR [score: 1 (0%)]

Dopamine is a major transmitter and neuromodulator in the CNS. This transmitter mediates its signaling through GPCRs of which the Dopamine D2 receptor class of ...

Development_Role of Activin A in cell differentiation and proliferation [score: 1 (0%)]

Activins are the members of the Transforming growth factor beta (TGF-beta) superfamily which participate in regulation of several biological processes, including cell differentiation and cell ...

Development_ACM2 and ACM4 activation of ERK [score: 1 (0%)]

ACM2 and ACM4 act via Guanine nucleotide binding proteins (G-protein) of G-protein alpha-i family. ACM2 can activate ...

Cell cycle_ESR1 regulation of G1/S transition [score: 1 (0%)]

Estradiol induces proliferation of estrogen receptor-positive cells. ESR1 (nuclear) activated by Estradiol acts like as ligand-dependent ...

Blood coagulation [score: 1 (0%)]

The haemostatic system maintains blood in a fluid state under normal conditions and responds to vessel injury by the rapid formation of a clot consisting of platelets and Fibrin. The traditional view of the regulation of blood coagulation is that the initiation phase is triggered by an extrinsic ...

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