Integrins are heterodimeric adhesion receptors composed of alpha- and beta-subunits. It is known that at least 18 distinct alpha subunits and 8 or more beta subunits lead to generation of 24 alpha/beta heterodimeric receptors. Most integrins recognize extracellular matrix (ECM) proteins, such ...

Deregulated neutrophilic inflammation and chronic infection lead to progressive destruction of the airways in cystic fibrosis (CF). In normal tissues, lipoxins are endogenous anti-inflammatory lipid mediators in regulation of neutrophilic inflammation [1]. In CF, production ...