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Regulatory Processes
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Protein Regulatory Pathways
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| Showing 1 - 8 out of 8 |
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G-protein signaling_Regulation of RAC1 activity [score: 1 (0%)]
Ras-related C3 botulinum toxin substrate 1 (Rac1) belongs
to the Rho subgroup of a family of small GTP-binding proteins (G-proteins) called
monomeric G-proteins. Proteins belonging to the Rho subgroup are involved in cytoskeletal
control, regulation of the formation of the stress fibers, focal ...
Cytoskeleton remodeling_FAK signaling [score: 1 (0%)]
The biological importance of PTK2 protein tyrosine kinase 2, or Focal
adhesion kinase 1 (FAK1)-mediated signal transduction is
underscored by the fact that this tyrosine kinase plays a fundamental role in embryonic
development, in control of cell migration, cell cycle progression, and in apoptosis.
Binding ...
Cytoskeleton remodeling_Reverse signaling by ephrin B [score: 1 (0%)]
Ephrin receptors and Ephrins
are both membrane bound, and following their interaction and clustering, each can
transduce signals that regulate cell responses [1].
Ephrin receptors activate reverse signaling through their
Ephrin ligands ...
Cytoskeleton remodeling_Role of PKA in cytoskeleton reorganisation [score: 1 (0%)]
A wide variety of soluble signaling mediators utilize the Protein
kinase cAMP-dependent (PKA) pathway to regulate cellular
processes including intermediary metabolism, ion channel conductivity, and transcription.
PKA plays a central role in cytoskeletal regulation and cell
migration. ...
Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases [score: 1 (0%)]
Ras homolog gene family, member A (RhoA) downstream
effector Rho-associated, coiled-coil containing protein kinase
(ROCK) directly phosphorylates LIM domain kinases 1 and 2
(LIMK1 and LIMK2) that in turn
phosphorylates Cofilin. Cofilin
exhibits Actin-depolymerizing ...
Cytoskeleton remodeling_Integrin outside-in signaling [score: 1 (0%)]
Integrins are heterodimeric adhesion receptors composed
of alpha- and beta-subunits. It is known that at least 18 distinct alpha subunits and 8
or more beta subunits lead to generation of 24 alpha/beta heterodimeric receptors. Most
integrins recognize extracellular matrix (ECM) proteins, such ...
Development_Slit-Robo signaling [score: 1 (0%)]
Attractive and repulsive receptors regulate cell motility and attachment in axon
guidance, vascular growth, immune cell regulation and tumor progression. There is strong
evidence that development of the nervous and vascular systems is controlled by common
cues.
Semaphorins, Ephrins, SLITs ...
Inhibitory action of Lipoxins on neutrophil migration [score: 1 (0%)]
Deregulated neutrophilic inflammation and chronic infection lead to progressive
destruction of the airways in cystic fibrosis (CF). In normal tissues, lipoxins are
endogenous anti-inflammatory lipid mediators in regulation of neutrophilic inflammation
[1]. In CF, production ...
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