Reverse signaling by Ephrin B
Ephrin receptors and Ephrins
are both membrane bound, and following their interaction and clustering, each can
transduce signals that regulate cell responses .
Ephrin receptors activate reverse ...
Neurotrophin family signaling
Factors of the neurotrophin family (NGF, BDNF and
neurotrophins NT-3 and NT-4/5), promote neuronal survival
or death. The best characterized receptors ...
Role of Parkin in the Ubiquitin-Proteasomal
Parkin is E3-ubiquitin-protein ligase that ubiquitinates
itself and specific substrate proteins playing a protective role by sequestering
misfolded proteins .
E3 ligases are part of the ...
MAG-dependent inhibition of neurite outgrowth
Neurotrophins are key regulators of the fate and shape of neuronal
cells. They act as guidance cues for growth cones by remodeling actin
cytoskeleton. Neurotrophins ...
Attractive and repulsive receptors regulate cell motility and attachment
in axon guidance, vascular growth, immune cell regulation and tumor
progression. There is strong evidence that ...
Role of CDK5 in neuronal death and survival
Cyclin-dependent kinase 5 (CDK5) is a member of the small
serine/threonine cyclin-dependent kinase (CDK) family.
Dopamine D2 receptor transactivation of EGFR
Dopamine is a major transmitter
and neuromodulator in the CNS. This transmitter mediates its signaling
through GPCRs of ...
Regulation and function of Amyloid
Amyloid precursor protein (APP) was initially detected in
cells of the central nervous system and is considered to be involved in the pathogenesis
of Alzheimer's disease . Since then, APP has