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Cytoskeleton remodeling_Reverse signaling by ephrin B [score: 1 (0%)]

Reverse signaling by Ephrin B

Ephrin receptors and Ephrins are both membrane bound, and following their interaction and clustering, each can transduce signals that regulate cell responses [1].

Ephrin receptors activate reverse ...

Development_Neurotrophin family signaling [score: 1 (0%)]

Neurotrophin family signaling

Factors of the neurotrophin family (NGF, BDNF and neurotrophins NT-3 and NT-4/5), promote neuronal survival or death. The best characterized receptors ...

Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway [score: 1 (0%)]

Role of Parkin in the Ubiquitin-Proteasomal Pathway

Parkin is E3-ubiquitin-protein ligase that ubiquitinates itself and specific substrate proteins playing a protective role by sequestering misfolded proteins [1].

E3 ligases are part of the ...

Development_MAG-dependent inhibition of neurite outgrowth [score: 1 (0%)]

MAG-dependent inhibition of neurite outgrowth

Neurotrophins are key regulators of the fate and shape of neuronal cells. They act as guidance cues for growth cones by remodeling actin cytoskeleton. Neurotrophins ...

Development_Slit-Robo signaling [score: 1 (0%)]

SLIT-ROBO signaling

Attractive and repulsive receptors regulate cell motility and attachment in axon guidance, vascular growth, immune cell regulation and tumor progression. There is strong evidence that ...

Apoptosis and survival_Role of CDK5 in neuronal death and survival [score: 1 (0%)]

Role of CDK5 in neuronal death and survival

Cyclin-dependent kinase 5 (CDK5) is a member of the small serine/threonine cyclin-dependent kinase (CDK) family.


Development_Dopamine D2 receptor transactivation of EGFR [score: 1 (0%)]

Dopamine D2 receptor transactivation of EGFR

Dopamine is a major transmitter and neuromodulator in the CNS. This transmitter mediates its signaling through GPCRs of ...

Regulation and function of Amyloid proteins [score: 1 (0%)]

Regulation and function of Amyloid proteins

Amyloid precursor protein (APP) was initially detected in cells of the central nervous system and is considered to be involved in the pathogenesis of Alzheimer's disease [1]. Since then, APP has been ...

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