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Attractive and repulsive receptors regulate cell motility and attachment in axon guidance, vascular growth, immune cell regulation and tumor progression. There is strong evidence that development of the nervous and vascular systems is controlled by common cues.

Semaphorins, Ephrins, SLITs ...

Inhibitory action of Lipoxins on neutrophil migration [score: 1 (0%)]

Deregulated neutrophilic inflammation and chronic infection lead to progressive destruction of the airways in cystic fibrosis (CF). In normal tissues, lipoxins are endogenous anti-inflammatory lipid mediators in regulation of neutrophilic inflammation [1]. In CF, production ...

Role of CDK5 in neuronal cell function [score: 1 (0%)]

Cyclin-dependent kinase 5 (CDK5) is a member of the small serine/threonine cyclin-dependent kinase family.

CDK5 is abundantly expressed in the adult brain. Moreover, it is present in subcellular fractions enriched for synaptic membranes, and localize to pre- and postsynaptic ...

Selected targets of SP1 [score: 1 (0%)]

Sp1 transcription factor (SP1) is a transcription factor involved in gene expression in the early development of an organism. It belongs to the Sp/KLF family of transcription factors. The SP1 transcription factor contains a zinc finger protein motif, by which it binds directly to DNA ...

Selected targets of EGR1 [score: 1 (0%)]

Early growth response 1 (EGR1) and Early growth response 2 (EGR2 (Krox20)) belong to the EGR family of C2H2-type zinc-finger proteins, which function as a transcriptional regulators.

EGR1 activates a wide variety of different targets, which are required for cell proliferation, ...

Selected targets of HNF transcription factors [score: 1 (0%)]

Hepatocyte nuclear factors (HNFs) are a group of phylogenetically unrelated transcription factors that regulate the transcription of a diverse group of genes. Hepatocyte nuclear factors are expressed predominately in the liver. However, HNFs are also expressed and play important roles in a number ...

Selected targets of NRSF [score: 1 (0%)]

RE1-silencing transcription factor (NRSF) is a member of the Kruppel-type zinc finger transcription factor family. It is a transcriptional repressor of neuronal genes in non-neuronal tissues. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer ...

Keratin filaments [score: 1 (0%)]

The cytoskeleton in most eukaryotic cells consists of three distinct, yet interconnected, filament systems: Actin filaments, Microtubules and intermediate filaments. Cell assembly is integrated by the network of intermediate filaments (IFs) and by their interactions with other cytoskeleton ...

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