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Transcription_CREB pathway [score: 1 (0%)]

Extracellular stimuli elicit changes in gene expression in target cells by activating intracellular protein kinase cascades that phosphorylate transcription factors within the nucleus. One of the best characterized stimulus-induced transcription factors is cyclic AMP (cAMP) responsive element binding ...

Cell cycle_Regulation of G1/S transition (part 1) [score: 1 (0%)]

DNA damage checkpoints are biochemical pathways that delay or halt cell cycle progression in response to DNA damage. Cell cycle proceeds in four phases in all somatic eukaryotic cells, G1, S, G2, and M, and one outside the cycle per se, G0 [1].

The G1/S cell cycle ...

Transcription_Ligand-dependent activation of the ESR1/SP pathway [score: 1 (0%)]

Estrogen receptor 1 (ESR1) is a major ligand-activated transcription factor, member of the family nuclear receptors [1]. ESR1 acts via two main pathways: a ligand-dependent and ligand-independent manner [2]. Activated by a ligand, ESR1 ...

Selected targets of SP1 [score: 1 (0%)]

Sp1 transcription factor (SP1) is a transcription factor involved in gene expression in the early development of an organism. It belongs to the Sp/KLF family of transcription factors. The SP1 transcription factor contains a zinc finger protein motif, by which it binds directly to DNA ...

Selected targets of c-Myc [score: 1 (0%)]

V-myc myelocytomatosis viral oncogene homolog (c-Myc) is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. c-Myc controls the transcription of a variety of different targets and regulates different processes, ...

Selected targets of EGR1 [score: 1 (0%)]

Early growth response 1 (EGR1) and Early growth response 2 (EGR2 (Krox20)) belong to the EGR family of C2H2-type zinc-finger proteins, which function as a transcriptional regulators.

EGR1 activates a wide variety of different targets, which are required for cell proliferation, ...

Selected targets of CREB1 [score: 1 (0%)]

cAMP responsive element binding protein 1 (CREB1) is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. CREB1 binds as a homodimer to the cAMP-responsive element, an octameric palindrome. CREB1 is phosphorylated by several protein kinases, ...

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