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Protein Regulatory Pathways
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G-protein signaling_N-RAS regulation pathway [score: 1 (0%)]
Neuroblastoma RAS viral (v-ras) oncogene homolog (N-RAS)
belongs to Ras family of small GTPases. It serves as a signal transducer from growth
factor receptors and activates numerous effector molecules resulting in cell growth,
differentiation and survival [1], [
DNA damage_ATM/ATR regulation of G1/S checkpoint [score: 1 (0%)]
DNA damage checkpoints are biochemical pathways that delay or arrest the cell cycle
progression in response to the DNA damage. All eukaryotic cells have four phases within
the cell cycle, G1, S, G2, and M, and one outside, G0 [1].
The G1/S checkpoint prevents cells ...
Cell cycle_Regulation of G1/S transition (part 2) [score: 1 (0%)]
The commencement of the cell cycle coincides with the production and the stabilization
of the Cyclin D. The D-type cyclins are essential for
synchronization of the cell cycle machinery with extracellular signals. [1]
Expression and stability of Cyclin D is ...
Signal transduction_PTEN pathway [score: 1 (0%)]
Phosphatase and tensin homolog (PTEN) is a known tumor
suppressor. It inhibits growth factor-induced cell proliferation, division and regulates
Integrin-mediated cell adhesion and survival [1].
PTEN antagonizes Phosphoinositide-3-kinase
(PI3K), ...
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