The haemostatic system maintains blood in a fluid state under normal conditions and responds to vessel injury by the rapid formation of a clot consisting of platelets and Fibrin. The traditional view of the regulation of blood coagulation is that the initiation phase is triggered by an extrinsic ...

Androgen and Estrogen receptors (Androgen receptor and ESR1 (nuclear)) function as steroid-hormone activated transcription factors. Upon binding the hormone ligand, receptors dissociate from accessory proteins, translocate into the nucleus, dimerize, and then stimulate transcription ...

Sp1 transcription factor (SP1) is a transcription factor involved in gene expression in the early development of an organism. It belongs to the Sp/KLF family of transcription factors. The SP1 transcription factor contains a zinc finger protein motif, by which it binds directly to DNA ...

V-myc myelocytomatosis viral oncogene homolog (c-Myc) is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. c-Myc controls the transcription of a variety of different targets and regulates different processes, ...

EGR1 activates a wide variety of different targets, which are required for cell proliferation, ...

cAMP responsive element binding protein 1 (CREB1) is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. CREB1 binds as a homodimer to the cAMP-responsive element, an octameric palindrome. CREB1 is phosphorylated by several protein kinases, ...