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Protein Regulatory Pathways
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| Showing 1 - 8 out of 8 |
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Cytoskeleton remodeling_Reverse signaling by ephrin B [score: 1 (0%)]
Ephrin receptors and Ephrins
are both membrane bound, and following their interaction and clustering, each can
transduce signals that regulate cell responses [1].
Ephrin receptors activate reverse signaling through their
Ephrin ligands ...
Chemotaxis_CXCR4 signaling pathway [score: 1 (0%)]
Chemokine (C-X-C motif) receptor-4 (CXCR4) is a G
protein-coupled receptor (GPCR). It is the only known receptor for stromal-derived
factor-1 (SDF-1), and SDF-1 is
the only known ligand for CXCR4 [1].
The CXCR4 is expressed in ...
Cell adhesion_Plasmin signaling [score: 1 (0%)]
Plasmin is a major fibrinolytic protease
with wide substrate specificity.
Plasminogen, a circulating plasma zymogen,
can be converted to Plasmin by tissue-type Plasminogen
activator (PLAT), Plasminogen activator urokinase
(PLAU), Coagulation factor XII,
or ...
Cell adhesion_PLAU signaling [score: 1 (0%)]
The binding of Plasminogen activator, urokinase (PLAU
(UPA)) to its glycosyl-phosphatidyl-inositol (GPI) anchored Plasminogen
activator, urokinase receptor (PLAUR (UPAR) (uPAR)) mediates
a variety of functions including vascular homeostasis, inflammation and tissue repair
[1].
PLAU ...
Cell adhesion_Tight junctions [score: 1 (0%)]
Multicellular organisms are separated from external environment by a layer of
epithelial cells whose integrity is maintained by intercellular junction complexes
composed of tight junctions (TJ), adherens junctions, and desmosomes. Tight cell
junctions serve as a physical barrier to prevent solutes ...
Blood coagulation [score: 1 (0%)]
The haemostatic system maintains blood in a fluid state under normal conditions and
responds to vessel injury by the rapid formation of a clot consisting of platelets and
Fibrin. The traditional view of the regulation of blood coagulation is that the
initiation phase is triggered by an extrinsic ...
Selected targets of Androgen and Estrogen receptors [score: 1 (0%)]
Androgen and Estrogen receptors (Androgen receptor and
ESR1 (nuclear)) function as steroid-hormone activated
transcription factors. Upon binding the hormone ligand, receptors dissociate from
accessory proteins, translocate into the nucleus, dimerize, and then stimulate
transcription ...
Selected targets of NRSF [score: 1 (0%)]
RE1-silencing transcription factor (NRSF) is a member of
the Kruppel-type zinc finger transcription factor family. It is a transcriptional
repressor of neuronal genes in non-neuronal tissues. It represses transcription by
binding a DNA sequence element called the neuron-restrictive silencer ...
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