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Regulatory Processes
Diseases
Protein Regulatory Pathways
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| Showing 1 - 8 out of 8 |
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Cell adhesion_Integrin-mediated cell adhesion and migration [score: 1 (0%)]
Cell migration is a coordinated process that involves rapid changes in the dynamics of
actin filaments, together with the formation and disassembly of cell adhesion sites.
External stimuli that control cell migration are transduced into intracellular
biochemical signals through the interactions of ...
Cytoskeleton remodeling_Reverse signaling by ephrin B [score: 1 (0%)]
Ephrin receptors and Ephrins
are both membrane bound, and following their interaction and clustering, each can
transduce signals that regulate cell responses [1].
Ephrin receptors activate reverse signaling through their
Ephrin ligands ...
Chemotaxis_CXCR4 signaling pathway [score: 1 (0%)]
Chemokine (C-X-C motif) receptor-4 (CXCR4) is a G
protein-coupled receptor (GPCR). It is the only known receptor for stromal-derived
factor-1 (SDF-1), and SDF-1 is
the only known ligand for CXCR4 [1].
The CXCR4 is expressed in ...
Cytoskeleton remodeling_Integrin outside-in signaling [score: 1 (0%)]
Integrins are heterodimeric adhesion receptors composed
of alpha- and beta-subunits. It is known that at least 18 distinct alpha subunits and 8
or more beta subunits lead to generation of 24 alpha/beta heterodimeric receptors. Most
integrins recognize extracellular matrix (ECM) proteins, such ...
Signal transduction_PTEN pathway [score: 1 (0%)]
Phosphatase and tensin homolog (PTEN) is a known tumor
suppressor. It inhibits growth factor-induced cell proliferation, division and regulates
Integrin-mediated cell adhesion and survival [1].
PTEN antagonizes Phosphoinositide-3-kinase
(PI3K), ...
Cell adhesion_PLAU signaling [score: 1 (0%)]
The binding of Plasminogen activator, urokinase (PLAU
(UPA)) to its glycosyl-phosphatidyl-inositol (GPI) anchored Plasminogen
activator, urokinase receptor (PLAUR (UPAR) (uPAR)) mediates
a variety of functions including vascular homeostasis, inflammation and tissue repair
[1].
PLAU ...
Development_Slit-Robo signaling [score: 1 (0%)]
Attractive and repulsive receptors regulate cell motility and attachment in axon
guidance, vascular growth, immune cell regulation and tumor progression. There is strong
evidence that development of the nervous and vascular systems is controlled by common
cues.
Semaphorins, Ephrins, SLITs ...
Transcription_Androgen Receptor nuclear signaling [score: 1 (0%)]
Androgen is the active metabolic product,
5alpha-Dihydrotestosterone, which is produced from the
transformation of Testosterone catalyzed by the
Steroid-5-alpha-reductase, alpha polypeptides 1 and 2 (S5AR1
and S5AR2) [1], [2]. ...
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