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Cell adhesion_Integrin-mediated cell adhesion and migration [score: 1 (0%)]
Cell migration is a coordinated process that involves rapid changes in the dynamics of
actin filaments, together with the formation and disassembly of cell adhesion sites.
External stimuli that control cell migration are transduced into intracellular
biochemical signals through the interactions of ...
Cytoskeleton remodeling_Reverse signaling by ephrin B [score: 1 (0%)]
Ephrin receptors and Ephrins
are both membrane bound, and following their interaction and clustering, each can
transduce signals that regulate cell responses [1].
Ephrin receptors activate reverse signaling through their
Ephrin ligands ...
Chemotaxis_CXCR4 signaling pathway [score: 1 (0%)]
Chemokine (C-X-C motif) receptor-4 (CXCR4) is a G
protein-coupled receptor (GPCR). It is the only known receptor for stromal-derived
factor-1 (SDF-1), and SDF-1 is
the only known ligand for CXCR4 [1].
The CXCR4 is expressed in ...
Cell adhesion_Plasmin signaling [score: 1 (0%)]
Plasmin is a major fibrinolytic protease
with wide substrate specificity.
Plasminogen, a circulating plasma zymogen,
can be converted to Plasmin by tissue-type Plasminogen
activator (PLAT), Plasminogen activator urokinase
(PLAU), Coagulation factor XII,
or ...
Cytoskeleton remodeling_Integrin outside-in signaling [score: 1 (0%)]
Integrins are heterodimeric adhesion receptors composed
of alpha- and beta-subunits. It is known that at least 18 distinct alpha subunits and 8
or more beta subunits lead to generation of 24 alpha/beta heterodimeric receptors. Most
integrins recognize extracellular matrix (ECM) proteins, such ...
Signal transduction_PTEN pathway [score: 1 (0%)]
Phosphatase and tensin homolog (PTEN) is a known tumor
suppressor. It inhibits growth factor-induced cell proliferation, division and regulates
Integrin-mediated cell adhesion and survival [1].
PTEN antagonizes Phosphoinositide-3-kinase
(PI3K), ...
Cell adhesion_PLAU signaling [score: 1 (0%)]
The binding of Plasminogen activator, urokinase (PLAU
(UPA)) to its glycosyl-phosphatidyl-inositol (GPI) anchored Plasminogen
activator, urokinase receptor (PLAUR (UPAR) (uPAR)) mediates
a variety of functions including vascular homeostasis, inflammation and tissue repair
[1].
PLAU ...
Cell adhesion_Integrin inside-out signaling [score: 1 (0%)]
The integrin family of transmembrane adhesion receptors mediates both cell-cell and
cell- extracellular matrix (ECM) adhesion. One important, rapid and reversible mechanism
for regulating adhesion is increasing the affinity of integrin receptors for their
extracellular ligands (integrin activation). ...
Cell adhesion_ECM remodeling [score: 1 (0%)]
Extracellular matrix (ECM) remodeling is involved in normal physiological processes,
such as embryonic development, reproduction, proliferation, cell motility and adhesion,
wound healing, angiogenesis, as well as in disease processes, such as arthritis and
metastasis. Matrix metalloproteinases (MMPs) ...
Cell adhesion_Endothelial cell contacts by non-junctional mechanisms [score: 1 (0%)]
Contacts between endothelial cells are of great importance for blood vessel
formation. The formation and maintenance of endothelial cell
contacts require the complex interplay of plasma membrane proteins, cytoskeleton
components, and signaling molecules. Some of these molecules are specifically ...
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