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Protein Regulatory Pathways
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Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins [score: 1 (0%)]
Apoptosis is an evolutionarily conserved type of programmed cell death essential for
development, homeostasis, and self-defense against infection. It can be triggered by a
number of factors including UV- or gamma-irradiation, chemotherapeutic drugs, or
signaling by death receptors. There are two ...
Apoptosis and survival_Caspase cascade [score: 1 (0%)]
Caspases are the central components of the apoptotic response. The apoptotic caspases
are generally divided into two classes: the initiator caspases, which include
caspase-2, -8,
-9 and -10 and the effector
caspases, which include caspases-3,
-6 and -7. ...
Transcription_P53 signaling pathway [score: 1 (0%)]
The Tumor protein p53 (p53) plays a critical role in
safeguarding the integrity of the genome. Upon activation,
p53 binds to the enhancer/promoter elements of downstream
target genes and regulates their transcription, through which it initiates cellular
programs that account for most ...
Apoptosis and survival_BAD phosphorylation [score: 1 (0%)]
BAD is a member of the BCL-2 family. BCL-2 family members
are regulators of the programmed cell death pathways.
BAD induces apoptosis by inhibiting antiapoptotic
BCL-2-family members - BCL-x,
Bcl-2, thereby allowing two other pro-apoptotic proteins,
BAK ...
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