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Regulatory Processes
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Protein Regulatory Pathways
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Signal transduction_PTEN pathway [score: 1 (0%)]
Phosphatase and tensin homolog (PTEN) is a known tumor
suppressor. It inhibits growth factor-induced cell proliferation, division and regulates
Integrin-mediated cell adhesion and survival [1].
PTEN antagonizes Phosphoinositide-3-kinase
(PI3K), ...
Transcription_Androgen Receptor nuclear signaling [score: 1 (0%)]
Androgen is the active metabolic product,
5alpha-Dihydrotestosterone, which is produced from the
transformation of Testosterone catalyzed by the
Steroid-5-alpha-reductase, alpha polypeptides 1 and 2 (S5AR1
and S5AR2) [1], [2]. ...
Selected targets of Androgen and Estrogen receptors [score: 1 (0%)]
Androgen and Estrogen receptors (Androgen receptor and
ESR1 (nuclear)) function as steroid-hormone activated
transcription factors. Upon binding the hormone ligand, receptors dissociate from
accessory proteins, translocate into the nucleus, dimerize, and then stimulate
transcription ...
Selected targets of SP1 [score: 1 (0%)]
Sp1 transcription factor (SP1) is a transcription factor
involved in gene expression in the early development of an organism. It belongs to the
Sp/KLF family of transcription factors. The SP1
transcription factor contains a zinc finger protein motif, by which it binds directly to
DNA ...
Selected targets of NRSF [score: 1 (0%)]
RE1-silencing transcription factor (NRSF) is a member of
the Kruppel-type zinc finger transcription factor family. It is a transcriptional
repressor of neuronal genes in non-neuronal tissues. It represses transcription by
binding a DNA sequence element called the neuron-restrictive silencer ...
Selected targets of CREB1 [score: 1 (0%)]
cAMP responsive element binding protein 1 (CREB1) is a
transcription factor that is a member of the leucine zipper family of DNA binding
proteins. CREB1 binds as a homodimer to the cAMP-responsive
element, an octameric palindrome. CREB1 is phosphorylated by
several protein kinases, ...
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