Apoptosis is an evolutionarily conserved type of programmed cell death essential for
development, homeostasis, and self-defense against infection. It can be triggered by a
number of factors including UV- or gamma-irradiation, chemotherapeutic ...
Caspases are the central components of the apoptotic response. The apoptotic caspases
are generally divided into two classes: the initiator caspases, which include
-9 and -10 and the effector
caspases, which include ...
Efficient and coordinated synthesis of the second messengers, including
Inositol-1,4,5-trisphosphate (IP3), Diacylglycerol
Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3), is
necessary for normal cell functioning. Production of secondary ...