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Apoptosis and survival_BAD phosphorylation [score: 1 (0%)]
BAD is a member of the BCL-2 family. BCL-2 family members
are regulators of the programmed cell death pathways.
BAD induces apoptosis by inhibiting antiapoptotic
BCL-2-family members - BCL-x,
Bcl-2, thereby allowing two other pro-apoptotic proteins,
BAK ...
Signal transduction_PKA signaling [score: 1 (0%)]
Protein kinase cAMP-dependent (PKA) is an enzyme playing
key role in a number of cellular processes. In its inactivated state,
PKA exists as a tetrameric complex of two catalytic subunits
(PKA-cat alpha and PKA-cat
beta) and two regulatory subunits (PKA-reg) (alpha ...
Signal transduction_PTEN pathway [score: 1 (0%)]
Phosphatase and tensin homolog (PTEN) is a known tumor
suppressor. It inhibits growth factor-induced cell proliferation, division and regulates
Integrin-mediated cell adhesion and survival [1].
PTEN antagonizes Phosphoinositide-3-kinase
(PI3K), ...
Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway [score: 1 (0%)]
The members of the tumour necrosis factor ligand family (TNFs) may induce both
apoptotic and anti-apoptotic pathways. TNFs transduces cellular responses through
activation of different TNF-receptors (TNFRs).
One important mechanism of cell survival is the activation of transcription of
different ...
Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway [score: 1 (0%)]
Members of the tumour necrosis factor ligand family (TNFs) may induce both apoptotic
and anti-apoptotic pathways. TNFs transduces cellular responses through activation of
different TNF-receptors (TNFRs).
One important mechanism of cell survival is activation of transcription of different
anti-apoptotic ...
Apoptosis and survival_Apoptotic TNF-family pathways [score: 1 (0%)]
Members of the tumour necrosis factor ligand family (TNFs) induce both apoptotic and
anti-apoptotic pathways. TNFs transduce cellular responses through activation of
different TNF-receptors (TNFRs) [1], [2], [3].
Different ...
Development_EPO-induced Jak-STAT pathway [score: 1 (0%)]
Erythropoiesis is a major pathway by which a pluripotent hematopoietic stem cell gives
rise to mature end stage cells. Erythropoietin (EPO) is a
lineage-specific hematopoietic growth factor required for survival, proliferation and
differentiation of committed erythroid progenitor cells [
Apoptosis and survival_Lymphotoxin-beta receptor signaling [score: 1 (0%)]
Lymphotoxin-beta receptor (LTBR), a member of the tumor
necrosis factor receptor superfamily, is essential for the development and organization
of secondary lymphoid tissue. The LTBR binds specific
ligands, such as the membrane form of lymphotoxin heterotrimer, Lymphotoxin-Alpha1Beta2
(TNF-beta/LTB ...
Transcription_Androgen Receptor nuclear signaling [score: 1 (0%)]
Androgen is the active metabolic product,
5alpha-Dihydrotestosterone, which is produced from the
transformation of Testosterone catalyzed by the
Steroid-5-alpha-reductase, alpha polypeptides 1 and 2 (S5AR1
and S5AR2) [1], [2]. ...
Development_Flt3 signaling [score: 1 (0%)]
FMS-like tyrosine kinase 3 (FLT3) belongs to the
subclass III family of receptor tyrosine kinases and it is expressed mainly in early
myeloid and lymphoid progenitor cells. Its activation leads mainly to proliferation and
survival [1], [2]. ...
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