The binding of Insulin to the extracellular domain of the Insulin receptor results in the activation of the tyrosine kinase activity of the receptor. Following the autophosphorylation, the Insulin receptor phosphorylates a number of intracellular substrates to initiate a series ...

(L)-Tyrosine, as other proteogenic aminoacids, conjugates with corresponding tRNA forming ...

Androstenedione originates either from the conversion of Dehydroepiandrosterone ...

Endogenous and exogenous estrogens undergo oxidative metabolism by hepatic microsomal cytochrome P-450. Aromatic hydroxylation at either the C2 or C4 position is a major route of Estradiol metabolism in humans and other mammals, although there is less 4-hydroxylation than 2-hydroxylation. ...

Endogenous and exogenous estrogens undergo oxidative metabolism by hepatic microsomal cytochrome P-450. Aromatic hydroxylation at either the C2 or C4 position is a major route of Estrone metabolism in humans and other mammals, although there are less 4-hydroxylation than 2-hydroxylation events. ...

Key enzymes involved in retinoid metabolisms are alcohol and aldehyde dehydrogenases that convert retinols to aldehydes and aldehydes to carboxylic acids, respectively. The first oxidation reaction is catalyzed by a large number of enzymes from the Dehydrogenase/reductase (SDR family), and by classic ...

Glutathione can be found in the cell in oxidized (Glutathione disulfide) and reduced (Glutathione) form. Reduced glutathione can be either directly formed from Glutathione disulfide as the result of activity of Glutathione reductase (GSHR) [1], ...

D-Glucose is the major energy source for mammalian cells as well as an important substrate for protein and lipid synthesis. Mammalian cells take up D-Glucose from extracellular fluid into the cell through two families of structurally related glucose transporters. Solute carrier family ...

Metabolism and binding studies with 2-Naphthylamine and many other arylamines have shown cytochrome P-450 catalysed N-hydroxylation to be a critical step in the activation of these compounds. Followed by glucuronidation and excretion of the glucuronides via the kidney, this reaction can account ...

Toxicity of Naphthalene in cell culture and animal models has to do with metabolisation of this compound by cytochrome P450 monooxygenases. Deactivation of Naphthalene involves epoxidation followed by glutathione conjugation and mercapturic acid formation [1]. Naphthalene ...