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Prostaglandin E2 (PGE2) is a crucial mediator of inflammatory pain sensitization. Prostaglandin E2 is produced in response to inflammation both in peripheral inflamed tissues and in the spinal cord [1].

Activation of the cytosolic phospholipase ...

Neurophysiological process_Glutamate regulation of Dopamine D1A receptor signaling [score: 1 (0%)]

Glutamic acid is the major excitatory neurotransmitter in the brain. The excitation of medium spiny neurons is regulated by a balance of glutamatergic inputs from corticostriatal and thalamostriatal pathways and dopaminergic inputs from the nigrostriatal pathway [1].

Dopamine ...

Development_Alpha-2 adrenergic receptor activation of ERK [score: 1 (0%)]

Alpha-2A adrenergic receptor, Alpha-2B adrenergic receptor, and Alpha-2C-1 adrenergic receptor participate in activation of Mitogen-activated protein kinases 1 and 3 (ERK1/2) via different ways [1].

Alpha-2A adrenergic receptor ...

Development_ACM2 and ACM4 activation of ERK [score: 1 (0%)]

ACM2 and ACM4 act via Guanine nucleotide binding proteins (G-protein) of G-protein alpha-i family. ACM2 can activate ...

Regulation of GABA signaling by Nicotine acetylcholine receptors [score: 1 (0%)]

Nicotinic acetylcholine receptors (nAChR) are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the postsynaptic side of the neuromuscular junctions. As ionotropic receptors, nAChR are directly linked to ion channels and do not ...

Manganese, Calcium and Iron-regulated proteins [score: 1 (0%)]

Proteins, regulated by binding of inorganic ions, are very important for different aspects of cell functioning.

There is a wide variety of Calcium, Manganese and Iron-regulated proteins inside and out of the cells.

Binding of Ca('2+) extracellular region to receptors of L-Glutamic ...

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