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Development_Neurotrophin family signaling [score: 1 (0%)]
Factors of the neurotrophin family (NGF,
BDNF and neurotrophins NT-3 and
NT-4/5), promote neuronal survival or death. The best
characterized receptors for these trophic factors are the tropomyosin-related tyrosine
kinase receptors TrkA, TrkB,
and TrkC, ...
Development_MAG-dependent inhibition of neurite outgrowth [score: 1 (0%)]
Neurotrophins are key regulators of the fate and shape of neuronal cells. They act as
guidance cues for growth cones by remodeling actin cytoskeleton. Neurotrophins
(NGF, BDNF,
NT-3 and NT-4/5) bind to two
structurally unrelated receptors, tyrosine kinase Trk receptors
(TrkA, ...
Cell adhesion_Cell-matrix glycoconjugates [score: 1 (0%)]
Extracellular matrix (ECM) is composed of several macromolecules bound together in a
complex network. This structure allows cells to adhere, migrate and interact.
Hyaluronic acid, a glycosaminoglycan, is a major component
of ECM. Hyaluronic acid-binding proteins such as hyaluronic
acid ...
Cytoskeleton remodeling_Neurofilaments [score: 1 (0%)]
Cytoskeleton of most eukaryotic cells consists of three distinct, yet interconnected,
filament systems: actin filaments,
microtubules and intermediate filaments (IF). IF network is
critically involved in cell shape control and imparts intracellular mechanical
strength.
The family ...
Development_Slit-Robo signaling [score: 1 (0%)]
Attractive and repulsive receptors regulate cell motility and attachment in axon
guidance, vascular growth, immune cell regulation and tumor progression. There is strong
evidence that development of the nervous and vascular systems is controlled by common
cues.
Semaphorins, Ephrins, SLITs ...
Apoptosis and survival_Role of CDK5 in neuronal death and survival [score: 1 (0%)]
Cyclin-dependent kinase 5 (CDK5) is a member of the small
serine/threonine cyclin-dependent kinase (CDK) family.
The best known role of CDK5 is its regulatoin of the
cytoskeleton architecture of the central nervous system (CNS). There is also some
evidence that links CDK5 ...
Neurophysiological process_PGE2-induced pain processing [score: 1 (0%)]
Prostaglandin E2 (PGE2) is a
crucial mediator of inflammatory pain sensitization. Prostaglandin
E2 is produced in response to inflammation both in peripheral inflamed
tissues and in the spinal cord [1].
Activation of the cytosolic phospholipase ...
Development_Alpha-2 adrenergic receptor activation of ERK [score: 1 (0%)]
Alpha-2A adrenergic receptor, Alpha-2B
adrenergic receptor, and Alpha-2C-1 adrenergic
receptor participate in activation of Mitogen-activated protein kinases 1
and 3 (ERK1/2) via different ways [1].
Alpha-2A adrenergic receptor ...
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