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G-protein signaling_Regulation of RAC1 activity [score: 1 (0%)]

Regulation of Rac1 activation

Ras-related C3 botulinum toxin substrate 1 (Rac1) belongs to the Rho subgroup of a family of small GTP-binding proteins (G-proteins) called monomeric G-proteins. Proteins belonging to the Rho subgroup are involved in cytoskeletal control, regulation ...

Cytoskeleton remodeling_FAK signaling [score: 1 (0%)]
FAK signaling

The biological importance of PTK2 protein tyrosine kinase 2, or Focal adhesion kinase 1 (FAK1)-mediated signal transduction is underscored by the fact that this tyrosine kinase plays a fundamental role in embryonic development, in control of cell migration, ...

G-protein signaling_G-Protein alpha-12 signaling pathway [score: 1 (0%)]

G-protein alpha-12 family signaling

Activation by ligands of G-protein coupled receptors that interact with the trimeric G-protein alpha-12/beta/gamma causes the exchange of GDP for GTP bound to G ...

Cytoskeleton remodeling_Reverse signaling by ephrin B [score: 1 (0%)]

Reverse signaling by Ephrin B

Ephrin receptors and Ephrins are both membrane bound, and following their interaction and clustering, each can transduce signals that regulate cell responses [1].

Ephrin receptors activate reverse ...

Cytoskeleton remodeling_Role of PKA in cytoskeleton reorganisation [score: 1 (0%)]

Role of PKA in cytoskeleton reorganisation

A wide variety of soluble signaling mediators utilize the Protein kinase cAMP-dependent (PKA) pathway to regulate cellular processes including intermediary ...

Signal transduction_Calcium signaling [score: 1 (0%)]

Calcium Signaling

Calcium (Ca('2+)) is a common second messenger that regulates many processes in the cell (e.g., contraction, secretion, synaptic transmission, fertilization, nuclear pore regulation, transcription). In cardiac myocytes and muscle cells, Ca('2+) ...

Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases [score: 1 (0%)]

Regulation of actin cytoskeleton by Rho GTPases

Ras homolog gene family, member A (RhoA) downstream effector Rho-associated, coiled-coil containing protein kinase (ROCK) directly phosphorylates ...

Cytoskeleton remodeling_Integrin outside-in signaling [score: 1 (0%)]

Integrin outside-in signaling

Integrins are heterodimeric adhesion receptors composed of alpha- and beta-subunits. It is known that at least 18 distinct alpha subunits and 8 or more beta subunits ...

Signal transduction_PKA signaling [score: 1 (0%)]

PKA signaling

Protein kinase cAMP-dependent (PKA) is an enzyme playing key role in a number of cellular processes. In its inactivated state, PKA exists as a tetrameric complex of two catalytic ...

Cytoskeleton remodeling_Neurofilaments [score: 1 (0%)]


Cytoskeleton of most eukaryotic cells consists of three distinct, yet interconnected, filament systems: actin filaments, microtubules and intermediate filaments (IF). IF network ...

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