There are two families of transcription factors that play pivotal roles during mammalian skeletal muscle differentiation. One of them includes MyoD family proteins (also called myogenic regulatory factors or MRFs), with four members Myf5, Myogenic differentiation 1 (MYOD), Myogenin (MYOG), ...

FGF2 induces biological responses by binding to ...

Both the Hedgehog and the Parathyroid hormone receptor (PTHR) signaling pathways take part in bone and cartilage development (12082161): Parathyroid hormone-like hormone (PTHrP) stimulates osteogenic cell proliferation [1]; Sonic hedgehog homolog (SHH) ...

Osteoporosis is a common disease affecting the majority of older women and a significant minority of older men. It is defined as the gradual reduction in bone strength with advancing age, particularly in post-menopause women. Osteoporosis is one of the major and growing health care problems around ...

V-myc myelocytomatosis viral oncogene homolog (c-Myc) is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. c-Myc controls the transcription of a variety of different targets and regulates different processes, ...