Glutamic acid is the major excitatory neurotransmitter in the brain. The excitation of medium spiny neurons is regulated by a balance of glutamatergic inputs from corticostriatal and thalamostriatal pathways and dopaminergic inputs from the nigrostriatal pathway [1].
Dopamine ...
Alpha-2A adrenergic receptor, Alpha-2B adrenergic receptor, and Alpha-2C-1 adrenergic receptor participate in activation of Mitogen-activated protein kinases 1 and 3 (ERK1/2) via different ways [1].
Alpha-2A adrenergic receptor ...
Dopamine is a major transmitter and neuromodulator in the CNS. This transmitter mediates its signaling through GPCRs of which the Dopamine D2 receptor class of ...
ACM2 and ACM4 act via Guanine nucleotide binding proteins (G-protein) of G-protein alpha-i family. ACM2 can activate ...