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Factors of the neurotrophin family (NGF, BDNF and neurotrophins NT-3 and NT-4/5), promote neuronal survival or death. The best characterized receptors for these trophic factors are the tropomyosin-related tyrosine kinase receptors ...

Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway [score: 1 (0%)]

Role of Parkin in the Ubiquitin-Proteasomal Pathway

Parkin is E3-ubiquitin-protein ligase that ubiquitinates itself and specific substrate proteins playing a protective role by sequestering misfolded proteins [1].

E3 ligases are part of the ...

Neurophysiological process_PGE2-induced pain processing [score: 1 (0%)]

PGE2-induced pain processing

Prostaglandin E2 (PGE2) is a crucial mediator of inflammatory pain sensitization. Prostaglandin E2 is produced in response to inflammation both in peripheral ...

Neurophysiological process_Glutamate regulation of Dopamine D1A receptor signaling [score: 1 (0%)]

Glutamic acid regulation of Dopamine D1A receptor signaling

Glutamic acid is the major excitatory neurotransmitter in the brain. The excitation of medium spiny neurons is regulated by a balance of glutamatergic inputs from corticostriatal and thalamostriatal ...

Development_Alpha-2 adrenergic receptor activation of ERK [score: 1 (0%)]

Alpha-2 adrenergic receptor activation of ERK

Alpha-2A adrenergic receptor, Alpha-2B adrenergic receptor, and Alpha-2C-1 adrenergic receptor participate in activation of Mitogen-activated protein kinases 1 and 3 (ERK1/2) via different ways [1].

Alpha-2A ...

Development_Dopamine D2 receptor transactivation of EGFR [score: 1 (0%)]

Dopamine D2 receptor transactivation of EGFR

Dopamine is a major transmitter and neuromodulator in the CNS. This transmitter mediates its signaling through GPCRs of which the Dopamine D2 ...

Development_ACM2 and ACM4 activation of ERK [score: 1 (0%)]
ACM2 and ACM4 activation of ERK
ACM2 and ACM4 act via Guanine nucleotide binding proteins (G-protein) of G-protein ...

Role of CDK5 in neuronal cell function [score: 1 (0%)]

Role of CDK5 in neuronal cell function

Cyclin-dependent kinase 5 (CDK5) is a member of the small serine/threonine cyclin-dependent kinase family.

CDK5 is abundantly expressed in the adult brain. Moreover, it is present in subcellular fractions enriched for synaptic ...

Regulation and function of Amyloid proteins [score: 1 (0%)]

Regulation and function of Amyloid proteins

Amyloid precursor protein (APP) was initially detected in cells of the central nervous system and is considered to be involved in the pathogenesis of Alzheimer's disease [1]. Since then, APP has been ...

Manganese, Calcium and Iron-regulated proteins [score: 1 (0%)]

Manganese, Calcium and Iron-regulated proteins

Proteins, regulated by binding of inorganic ions, are very important for different aspects of cell functioning.

There is a wide variety of Calcium, Manganese and Iron-regulated proteins inside and out of the cells.

Binding ...

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