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Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins [score: 1 (0%)]

Regulation of Apoptosis by Mitochondrial Proteins

Apoptosis is an evolutionarily conserved type of programmed cell death essential for development, homeostasis, and self-defense against infection. It can ...

Apoptosis and survival_Caspase cascade [score: 1 (0%)]

Caspase cascade

Caspases are the central components of the apoptotic response. The apoptotic caspases are generally divided into two classes: the initiator caspases, which include ...

Transcription_P53 signaling pathway [score: 1 (0%)]

p53 signaling pathway

The Tumor protein p53 (p53) plays a critical role in safeguarding the integrity of the genome. Upon activation, p53 binds to the enhancer/promoter elements of downstream ...

Apoptosis and survival_FAS signaling cascades [score: 1 (0%)]

FAS signaling cascade

Death receptors such as FasR belong to a Tumour Necrosis Factor (TNF) superfamily of receptors involved in proliferation, differentiation and apoptosis. FasR is ubiquitously ...

Apoptosis and survival_TNFR1 signaling pathway [score: 1 (0%)]
Role TNF-alpha in apoptosis

The tumor necrosis factor (TNF-alpha) is a potent cytokine produced by many cell types, including macrophages, monocytes, lymphocytes, keratinocytes and fibroblasts, in response ...

Signal transduction_Erk Interactions: Inhibition of Erk [score: 1 (0%)]

Erk Interactions: Inhibition of Erk

Mitogen-activated protein kinase (MAPK) pathways regulate a variety of physiological processes, such as cell growth, differentiation, and apoptotic cell death. To date, ...

G-protein signaling_G-Protein alpha-12 signaling pathway [score: 1 (0%)]

G-protein alpha-12 family signaling

Activation by ligands of G-protein coupled receptors that interact with the trimeric G-protein alpha-12/beta/gamma causes the exchange of GDP for GTP bound to G ...

Signal transduction_AKT signaling [score: 1 (0%)]
AKT signaling

RAC-alpha serine/threonine kinases (AKTs) are crucial mediators of various cellular process, such as apoptosis, regulation of cell cycle, protein synthesis and regulation of metabolism. The ...

Signal transduction_IP3 signaling [score: 1 (0%)]

IP3 signaling

Efficient and coordinated synthesis of the second messengers, including Inositol-1,4,5-trisphosphate (IP3), Diacylglycerol (DAG), and Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3), is necessary for normal cell functioning. Production of secondary ...

Development_Neurotrophin family signaling [score: 1 (0%)]

Neurotrophin family signaling

Factors of the neurotrophin family (NGF, BDNF and neurotrophins NT-3 and NT-4/5), promote neuronal survival or death. The best characterized receptors ...

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