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Apoptosis and survival_TNFR1 signaling pathway [score: 1 (0%)]
Role TNF-alpha in apoptosis
The tumor necrosis factor (
TNF-alpha) is a potent cytokine
produced by many cell types, including macrophages, monocytes,
lymphocytes, keratinocytes and fibroblasts, in response ...
Development_EGFR signaling pathway [score: 1 (0%)]
EGFR signaling pathway
Epidermal growth factor receptor (
EGFR) belongs to the ERBB
family of receptor tyrosine kinases that contains four closely related
members EGFR and ERBB2-4. They couple ...
Immune response_IL-6 signaling pathway [score: 1 (0%)]
IL-6 signaling pathway
IL-6) is a pleiotropic cytokine produced by
various types of lymphoid and nonlymphoid cells, such as T cells, B
cells, monocytes, fibroblasts, keratinocytes, ...
Immune response_MIF in innate immunity response [score: 1 (0%)]
MIF in innate immunity response
The cytokine Macrophage migration inhibitory factor (
MIF) is an
integral mediator of the innate immune system. Monocytes, macrophages
and lymphocytes constitutively ...
Immune response_IL-22 signaling pathway [score: 1 (0%)]
IL-22 signaling pathway
IL-22) is a member of the IL-10 family of
cytokines. The major sources of IL-22 are activated T cells,
especially upon type 1 polarization, and natural ...
Signal transduction_JNK pathway [score: 1 (0%)]
The Mitogen-activated protein kinases 8-10
JNK(MAPK8-10)) belong to a sub-group of evolutionarily
conserved mitogen-activated protein kinases (MAPK) activated primarily by cytokines,
growth factors and by exposure to environmental stress. JNK(MAPK8-10)
Immune response_TLR2 and TLR4 signaling pathways [score: 1 (0%)]
TLR2 and TLR4 signaling pathways
TLR2 and TLR4 induce MyD88/ IRAK/ TRAF6-dependent
pathway in target cells, leading to activation of transcription factors NF-kB, ...
Immune response_IL-1 signaling pathway [score: 1 (0%)]
IL-1 signaling pathway
Interleukin-1 (IL-1) is a proinflammatory cytokine produced by activated
macrophages, endothelial cells, B cells and fibroblasts. IL-1 stimulates
a broad spectrum of immune and inflammatory ...
Cell adhesion_ECM remodeling [score: 1 (0%)]
Extracellular matrix (ECM) remodeling is involved in normal physiological processes,
such as embryonic development, reproduction, proliferation, cell motility and adhesion,
wound healing, angiogenesis, as well as in disease processes, such as arthritis and