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Apoptosis and survival_Caspase cascade [score: 1 (0%)]
Caspases are the central components of the apoptotic response. The
apoptotic caspases are generally divided into two classes: the initiator
caspases, which include ...
Transcription_P53 signaling pathway [score: 1 (0%)]
p53 signaling pathway
The Tumor protein p53 (
p53) plays a critical role in safeguarding
the integrity of the genome. Upon activation, p53 binds to the
enhancer/promoter elements of downstream ...
Apoptosis and survival_FAS signaling cascades [score: 1 (0%)]
FAS signaling cascade
Death receptors such as FasR belong to a Tumour Necrosis Factor (TNF)
superfamily of receptors involved in proliferation, differentiation and
FasR is ubiquitously ...
Apoptosis and survival_TNFR1 signaling pathway [score: 1 (0%)]
Role TNF-alpha in apoptosis
The tumor necrosis factor (
TNF-alpha) is a potent cytokine
produced by many cell types, including macrophages, monocytes,
lymphocytes, keratinocytes and fibroblasts, in response ...
Signal transduction_Erk Interactions: Inhibition of Erk [score: 1 (0%)]
Erk Interactions: Inhibition of Erk
Mitogen-activated protein kinase (MAPK) pathways regulate a variety of
physiological processes, such as cell growth, differentiation, and
apoptotic cell death. To date, ...
Signal transduction_AKT signaling [score: 1 (0%)]
RAC-alpha serine/threonine kinases (
AKTs) are crucial mediators
of various cellular process, such as apoptosis, regulation of cell
cycle, protein synthesis and regulation of metabolism. The ...
Signal transduction_IP3 signaling [score: 1 (0%)]
Efficient and coordinated synthesis of the second messengers, including
( DAG), and
Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3), is
necessary for normal cell functioning. Production of secondary ...
Development_Neurotrophin family signaling [score: 1 (0%)]
Neurotrophin family signaling
Factors of the neurotrophin family (
NGF, BDNF and
neurotrophins NT-3 and NT-4/5), promote neuronal survival
or death. The best characterized receptors ...