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Apoptosis and survival_Apoptotic TNF-family pathways [score: 1 (0%)]

Members of the tumour necrosis factor ligand family (TNFs) induce both apoptotic and anti-apoptotic pathways. TNFs transduce cellular responses through activation of different TNF-receptors (TNFRs) [1], [2], [3].

Different ...

Apoptosis and survival_Lymphotoxin-beta receptor signaling [score: 1 (0%)]

Lymphotoxin-beta receptor (LTBR), a member of the tumor necrosis factor receptor superfamily, is essential for the development and organization of secondary lymphoid tissue. The LTBR binds specific ligands, such as the membrane form of lymphotoxin heterotrimer, Lymphotoxin-Alpha1Beta2 (TNF-beta/LTB ...

Immune response_MIF-mediated glucocorticoid regulation [score: 1 (0%)]

Glucocorticoids are potent anti-inflammatory and immunosuppressive agents. They inhibit synthesis of almost all known cytokines, enzymes involved in the inflammatory process and several cell surface molecules required for immune function. Glucocorticoids mediate these effects via the ...

Immune response_Oncostatin M signaling via MAPK in human cells [score: 1 (0%)]

Oncostatin M is a multifunctional cytokine produced by activated T lymphocytes, monocytes and microglia. It is structurally and functionally related to the subfamily of hematopoietic and neurotrophic cytokines known as the Interleukin 6 (IL6)-type cytokine family [1].

Human ...

Apoptosis and survival_APRIL and BAFF signaling [score: 1 (0%)]

Tumor necrosis factor (ligand) superfamily members 13 and 13b (APRIL and BAFF) and their receptors - Tumor necrosis factor receptor superfamily members 13C, 17 and 13B (BAFF-R, BCMA and TACI) - play important roles in the B-cell and T-cell arms of the immune system ...

Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2 [score: 1 (0%)]

Estradiol exerts an anti-apoptotic effect on a wide variety of tissues that is mediated via activation of nuclear form of ESR1 (nuclear) and ESR2

Immune response_IL-12-induced IFN-gamma production [score: 1 (0%)]

IL-12 is an important cytokine involved in production of IFN-gamma by T cells and NK cells, and plays an important role in T-helper ...

Selected targets of SP1 [score: 1 (0%)]

Sp1 transcription factor (SP1) is a transcription factor involved in gene expression in the early development of an organism. It belongs to the Sp/KLF family of transcription factors. The SP1 transcription factor contains a zinc finger protein motif, by which it binds directly to DNA ...

Selected targets of C/EBP [score: 1 (0%)]

CCAAT/enhancer binding proteins (C/EBP) are a group of bZIP transcription factors, consisting of C/EBPalpha, beta, delta, epsilon, gamma and zeta, which can bind as homodimers to certain promoters and enhancers. C/EBP is important in the regulation ...

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