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Immune response_IL-2 activation and signaling pathway [score: 1 (0%)]
Interleukin-2 (IL-2) is a T-Cell-derived cytokine
important in the regulation of growth and differentiation of T-Cells, B-Cells, natural
killer cells, glioma cells, and cells of the monocyte lineage.
IL-2 signaling is mediated by a multichain
IL-2 receptor complex consisting ...
Immune response_IL-4 signaling pathway [score: 1 (0%)]
Interleukin-4 (IL-4) is a T cell derived multifunctional
cytokine that plays a critical role in the regulation of immune responses.
IL-4 induces Th2 (T helper 2) differentiation, causes
macrophage suppression, and stimulates B cell production of Immunoglobulins E, G1 and G4
(IgE, ...
Immune response _IFN gamma signaling pathway [score: 1 (0%)]
Interferons (IFNs) are pleiotropic cytokines that mediate anti-viral responses,
inhibit proliferation and participate in immune surveillance and tumor suppression by
inducing the transcription of a number of IFN-stimulated genes. The IFN family includes
two main classes of related cytokines, type ...
Immune response_IL-10 signaling pathway [score: 1 (0%)]
Interleukin-10 (IL-10) is a pleiotropic cytokine with
important immunoregulatory functions. Its actions influence activities of many of the
cell-types in the immune system. It is also a cytokine with potent anti-inflammatory
properties: it represses the expression of inflammatory cytokines, ...
Development_Thrombopoietin-regulated cell processes [score: 1 (0%)]
Thrombopoietin is a hormone involved in biological
effects on a broad spectrum of hematopoietic progenitor cells, including stem cells. It
supports stem cell survival and expansion. It is primarily a key physiological regulator
of steady-state megakaryocytopoiesis, the process of megakaryocyte ...
Immune response_BCR pathway [score: 1 (0%)]
The BCR (B-Cell antigen Receptor) plays a critical role in development, survival, and
activation of B lymphocytes. The BCR is composed of membrane immunoglobulin
(IgM) molecules associated with CD79a molecule,
immunoglobulin-associated alpha - CD79b molecule, immunoglobulin-associated beta
heterodimers ...
Immune response _CCR3 signaling in eosinophils [score: 1 (0%)]
Human eosinophils are key effector cells implicated in a number of chronic
inflammatory reactions, associated with bronchial asthma, allergic-inflammatory diseases
and parasitic infections. Chemoattractants/chemokines, generated at the affected sites,
promote migration of eosinophils from vasculature ...
Development_EPO-induced MAPK pathway [score: 1 (0%)]
Erythropoiesis is the main pathway of pluripotent hematopoietic stem cell development
into mature end stage cells. Erythropoietin (Epo) is a major
lineage-specific hematopoietic growth factor required for survival, proliferation and
differentiation of committed erythroid progenitor cells [
Development_Flt3 signaling [score: 1 (0%)]
FMS-like tyrosine kinase 3 (FLT3) belongs to the
subclass III family of receptor tyrosine kinases and it is expressed mainly in early
myeloid and lymphoid progenitor cells. Its activation leads mainly to proliferation and
survival [1], [2]. ...
Immune response_CD16 signaling in NK cells [score: 1 (0%)]
Natural killer (NK) cells mediate antibody-depend cellular cytotoxicity through the Fc
fragment of IgG, low affinity IIIa and receptor (CD16a) (Fc gamma RIII
alpha (CD16)) [1], [2]. The preferred ligands
for Fc gamma RIII alpha (CD16) ...
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