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Immune response_IL-2 activation and signaling pathway [score: 1 (0%)]
Interleukin-2 (IL-2) is a T-Cell-derived cytokine
important in the regulation of growth and differentiation of T-Cells, B-Cells, natural
killer cells, glioma cells, and cells of the monocyte lineage.
IL-2 signaling is mediated by a multichain
IL-2 receptor complex consisting ...
Immune response_T cell receptor signaling pathway [score: 1 (0%)]
T cell receptors (TCR) play a key role in functioning of
T cells and formation of the immunological synapse. It provides connection between T cell
and the antigen-presenting cell (APC) [1]. TCRs are composed of
ligand-binding subunits, the alpha and beta chains, ...
Immune response_IL-6 signaling pathway [score: 1 (0%)]
Interleukin-6 (IL-6) is a pleiotropic cytokine produced
by various types of lymphoid and nonlymphoid cells, such as T cells, B cells, monocytes,
fibroblasts, keratinocytes, endothelial cells, mesangial cells and several tumor cells.
IL-6 provokes a broad range of cellular and physiological
responses, ...
Immune response _CCR3 signaling in eosinophils [score: 1 (0%)]
Human eosinophils are key effector cells implicated in a number of chronic
inflammatory reactions, associated with bronchial asthma, allergic-inflammatory diseases
and parasitic infections. Chemoattractants/chemokines, generated at the affected sites,
promote migration of eosinophils from vasculature ...
Development_EPO-induced Jak-STAT pathway [score: 1 (0%)]
Erythropoiesis is a major pathway by which a pluripotent hematopoietic stem cell gives
rise to mature end stage cells. Erythropoietin (EPO) is a
lineage-specific hematopoietic growth factor required for survival, proliferation and
differentiation of committed erythroid progenitor cells [
Development_EPO-induced MAPK pathway [score: 1 (0%)]
Erythropoiesis is the main pathway of pluripotent hematopoietic stem cell development
into mature end stage cells. Erythropoietin (Epo) is a major
lineage-specific hematopoietic growth factor required for survival, proliferation and
differentiation of committed erythroid progenitor cells [
Immune response_Role of integrins in NK cells cytotoxicity [score: 1 (0%)]
Natural killer (NK) cells are lymphocytes of innate immune system. They recognize and
kill aberrant cells without immunization or pre-activation, by releasing cytotoxic
granules and rapidly produce soluble factors - chemokines and cytokines.
NK cells feature a variety of cell surface receptors, ...
Development_Flt3 signaling [score: 1 (0%)]
FMS-like tyrosine kinase 3 (FLT3) belongs to the
subclass III family of receptor tyrosine kinases and it is expressed mainly in early
myeloid and lymphoid progenitor cells. Its activation leads mainly to proliferation and
survival [1], [2]. ...
Immune response_CD16 signaling in NK cells [score: 1 (0%)]
Natural killer (NK) cells mediate antibody-depend cellular cytotoxicity through the Fc
fragment of IgG, low affinity IIIa and receptor (CD16a) (Fc gamma RIII
alpha (CD16)) [1], [2]. The preferred ligands
for Fc gamma RIII alpha (CD16) ...
Development_Endothelin-1/EDNRA transactivation of EGFR [score: 1 (0%)]
Endothelin-1, a potent endothelium-derived
vasoconstrictor peptide, exerts a growth-promoting effect on vascular smooth muscle
cells, implicating its pathogenic role in vascular remodeling.
Endothelin-1 action is initiated by its binding to
Endothelin receptor type A (EDNRA) ...
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